Generalization of a genetic risk score for time to first albuminuria in children with sickle cell anaemia: SCCRIP cohort study results.

Autor: Rashkin SR; Center for Applied Bioinformatics, St. Jude Children's Research Hospital, Memphis, TN, USA.; Department of Hematology, St. Jude Children's Research Hospital, Memphis, TN, USA., Rampersaud E; Center for Applied Bioinformatics, St. Jude Children's Research Hospital, Memphis, TN, USA., Kang G; Department of Biostatistics, St. Jude Children's Research Hospital, Memphis, TN, USA., Ataga KI; Center for Sickle Cell Disease, University of Tennessee Health Science Center, Memphis, TN, USA., Hankins JS; Department of Hematology, St. Jude Children's Research Hospital, Memphis, TN, USA., Wang W; Department of Hematology, St. Jude Children's Research Hospital, Memphis, TN, USA., Estepp JH; Department of Hematology, St. Jude Children's Research Hospital, Memphis, TN, USA.; Department of Global Pediatric Medicine, St. Jude Children's Research Hospital, Memphis, TN, USA., Weiss MJ; Department of Hematology, St. Jude Children's Research Hospital, Memphis, TN, USA., Lebensburger J; Division of Pediatric Hematology and Oncology, University of Alabama at Birmingham, Birmingham, AL, USA., Zahr RS; Division of Pediatric Nephrology and Hypertension, University of Tennessee Health Science Center, Memphis, TN, USA.
Jazyk: angličtina
Zdroj: British journal of haematology [Br J Haematol] 2021 Jul; Vol. 194 (2), pp. 469-473. Date of Electronic Publication: 2021 Jun 16.
DOI: 10.1111/bjh.17647
Abstrakt: Albuminuria predicts kidney disease progression in individuals with sickle cell anaemia (SCA); however, earlier prediction of kidney disease with introduction of reno-protective therapies prior to the onset of albuminuria may attenuate disease progression. A genetic risk score (GRS) for SCA-related nephropathy may provide an improved one-time test for early identification of high-risk patients. We utilized a GRS from a recent, large, trans-ethnic meta-analysis to identify three single nucleotide polymorphisms that associate individually and in a GRS with time to first albuminuria episode in children with SCA.
(© 2021 British Society for Haematology and John Wiley & Sons Ltd.)
Databáze: MEDLINE
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