Comparison of Two Different Intravitreal Injection Techniques.
Autor: | Uy HS; Department of Ophthalmology and Visual Sciences, University of the Philippines, Manila, Philippines.; Peregrine Eye and Laser Institute, Makati City, Philippines.; St. Luke's Medical Center, Quezon City, Philippines., Artiaga JCM; St. Luke's Medical Center Global City, Taguig City, Philippines. |
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Jazyk: | angličtina |
Zdroj: | Clinical ophthalmology (Auckland, N.Z.) [Clin Ophthalmol] 2021 Jun 08; Vol. 15, pp. 2383-2389. Date of Electronic Publication: 2021 Jun 08 (Print Publication: 2021). |
DOI: | 10.2147/OPTH.S309501 |
Abstrakt: | Objective: To compare the effectiveness, procedure time and safety outcomes of two different intravitreal injections (IVI) techniques. Methods: This was a prospective, single-center, randomized clinical trial of 200 adult eyes receiving intravitreal medications for various indications. Eyes were assigned (1:1) to undergo IVI using either an intravitreal injection guide (IIG) (n= 100) or conventional dual blade speculum plus surgical caliper (DBS) (n=100). All IVI were administered using a 30-gauge needle placed 4 mm posterior to the inferior limbus. The main outcome measures were rate of successful IVI administration, procedure time (seconds) as measured by a stopwatch from application to removal of IIG or DBS, patient preference for IVI technique and adverse events. Results: The two groups were similar in terms of mean age (P=0.398), laterality (P=0.671), indication for treatment (P=0.175) and medication type (P=0.489). All IVI procedures were successfully completed in both groups. The mean procedure time was shorter using the IIG (9.94 ± 2.87 seconds) versus DBS (21.85 ± 7.25 seconds) technique (P ≤ 0.01). The incidence of post-injection subconjunctival hemorrhage was higher when the DBS was applied (OR = 2.35, 95% CI = 1.22-4.53). Patients with previous history of IVI preferred the IIG over the DBS. No other injection-related adverse events were observed in both groups. Conclusion: DBS and IIG techniques are similarly effective and safe for the administration of intravitreal medications. The IIG appears to significantly reduce procedure time, be associated with a lower incidence of subconjunctival hemorrhage and engender better patient acceptance. Clinical Trial Registration: ClinicalTrials.gov (NCT04455399). Competing Interests: The authors report no conflicts of interest in this work. (© 2021 Uy and Artiaga.) |
Databáze: | MEDLINE |
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