Principles of regeneration revealed by the planarian eye.

Autor: Reddien PW; Whitehead Institute for Biomedical Research, Cambridge, MA, 02142, USA; Department of Biology, MIT, Cambridge, MA, 02139, USA; Howard Hughes Medical Institute, MIT, Cambridge, MA, 02139, USA. Electronic address: reddien@wi.mit.edu.
Jazyk: angličtina
Zdroj: Current opinion in cell biology [Curr Opin Cell Biol] 2021 Dec; Vol. 73, pp. 19-25. Date of Electronic Publication: 2021 Jun 13.
DOI: 10.1016/j.ceb.2021.05.001
Abstrakt: One approach to elucidating the principles of regeneration is to investigate mechanisms that regenerate a target organ. Planarian eyes are discrete, visible structures that are dispensable for viability, making them powerful for studying the logic of regeneration. Fate specification in eye regeneration occurs in stem cells (neoblasts), generating eye progenitors. Eye progenitor production is not responsive to the presence or absence of the eye, with regeneration explained by constant progenitor production in the appropriate positional environment. Eye progenitors display coarse spatial specification. A combination of eye-extrinsic cues and self-organization with differentiated eye cells dictate where migratory eye progenitors target. Finally, guidepost-like cells influence regenerating axons to facilitate the restoration of eye circuitry. These findings from the eye as a case study present a model that explains how regeneration can occur.
Competing Interests: Conflict of interest statement Nothing declared.
(Copyright © 2021 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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