Novel gammaherpesvirus associated with primary gastric T-cell lymphoma in a free-ranging giant armadillo in Brazil.

Autor: Navas-Suárez PE; Laboratory of Wildlife Comparative Pathology, School of Veterinary Medicine and Animal Sciences, University of São Paulo, São Paulo, São Paulo State, Brazil., Sacristán C; Laboratory of Wildlife Comparative Pathology, School of Veterinary Medicine and Animal Sciences, University of São Paulo, São Paulo, São Paulo State, Brazil., Kluyber D; Giant Armadillo Conservation Project, Instituto de Conservação de Animais Silvestres (ICAS), Campo, Grande, Brazil.; Naples Zoo at Caribbeans Gardens, Naples, Florida, USA., Yogui DR; Giant Armadillo Conservation Project, Instituto de Conservação de Animais Silvestres (ICAS), Campo, Grande, Brazil.; The Royal Zoological Society of Scotland (RZSS), Edinburgh Zoo, Edinburgh, Scotland., Alves AC; Giant Armadillo Conservation Project, Instituto de Conservação de Animais Silvestres (ICAS), Campo, Grande, Brazil., Dalazen GT; Laboratory of Wildlife Comparative Pathology, School of Veterinary Medicine and Animal Sciences, University of São Paulo, São Paulo, São Paulo State, Brazil., Díaz-Delgado J; Texas A&M Veterinary Medical Diagnostic Laboratory, College Station, Texas, USA., Guerra JM; Center of Pathology, Adolfo Lutz Institute, São Paulo, Brazil., de Azevedo Fernandes NCC; Center of Pathology, Adolfo Lutz Institute, São Paulo, Brazil., Réssio RA; Center of Pathology, Adolfo Lutz Institute, São Paulo, Brazil., da Silva TC; Department of Pathology, School of Veterinary Medicine and Animal Sciences, University of São Paulo, São Paulo, São Paulo State, Brazil., Cogliati B; Department of Pathology, School of Veterinary Medicine and Animal Sciences, University of São Paulo, São Paulo, São Paulo State, Brazil., Desbiez ALJ; Giant Armadillo Conservation Project, Instituto de Conservação de Animais Silvestres (ICAS), Campo, Grande, Brazil.;  , Nashville Zoo, Nashville, USA., Catão-Dias JL; Laboratory of Wildlife Comparative Pathology, School of Veterinary Medicine and Animal Sciences, University of São Paulo, São Paulo, São Paulo State, Brazil.
Jazyk: angličtina
Zdroj: Transboundary and emerging diseases [Transbound Emerg Dis] 2022 Jul; Vol. 69 (4), pp. 2045-2051. Date of Electronic Publication: 2021 Jun 24.
DOI: 10.1111/tbed.14189
Abstrakt: The number of viral-associated neoplasms reported in wildlife has increased over the last decades, likely because of growing research efforts and a potentially greater burden of carcinogenic pathogens. Herein, we describe a primary gastric T-cell lymphoma in one free-ranging giant armadillo (Priodontes maximus) from Brazilian Pantanal infected by a novel gammaherpesvirus, proposed as Cingulatid gammaherpesvirus 1 (CiHV-1). By chromogenic in situ hybridisation against Epstein-Barr virus some neoplastic cells were labeled. Subsequently, a molecular screening was carried out to detect the occurrence of this pathogen in other giant armadillos in the same region. Overall, this novel virus was detected in 14.3% (3/21) of the tested giant armadillos. We suggest this herpesvirus, the first in Xenarthra, as a plausible aetiology of the neoplasm. The implications of CiHV-1 for this species are uncertain; while no outbreaks of disease have been recorded, the present study raises concerns. Further research is warranted to assess the real significance of CiHV-1 and its potential oncogenic role in this species.
(© 2021 Wiley-VCH GmbH.)
Databáze: MEDLINE
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