SARS-CoV-2 and its new variants: a comprehensive review on nanotechnological application insights into potential approaches.

Autor: Raja RK; Department of Microbiology, Alagappa University, Karaikudi, Tamil Nadu 630003 India., Nguyen-Tri P; Department of Chemistry, Biochemistry and Physics, University du Québec àTrois-Rivieres, Trois-Rivieres, Canada., Balasubramani G; Aquatic Animal Health and Environmental Division, ICAR-Central Institute of Brackishwater Aquaculture, Chennai, 600028 India., Alagarsamy A; Department of Microbiology, Alagappa University, Karaikudi, Tamil Nadu 630003 India., Hazir S; Department of Biology, Faculty of Science and Arts, Adnan Menderes University, Aydin, Turkey., Ladhari S; Department of Chemistry, Biochemistry and Physics, University du Québec àTrois-Rivieres, Trois-Rivieres, Canada., Saidi A; Institut de Recherche Robert-Sauvé en Santé et en Sécurité du Travail (IRSST), 505 Boulevard de Maisonneuve O, Montréal, QC H3A 3C2 Canada., Pugazhendhi A; Innovative Green Product Synthesis and Renewable Environment Development Research Group, Faculty of Environment and Labour Safety, Ton Duc Thang University, Ho Chi Minh City, Vietnam., Samy AA; College of Medical and Health Sciences, Wollega University, Nekemte, Ethiopia.
Jazyk: angličtina
Zdroj: Applied nanoscience [Appl Nanosci] 2023; Vol. 13 (1), pp. 65-93. Date of Electronic Publication: 2021 Jun 10.
DOI: 10.1007/s13204-021-01900-w
Abstrakt: SARS-CoV-2 (COVID-19) spreads and develops quickly worldwide as a new global crisis which has left deep socio-economic damage and massive human mortality. This virus accounts for the ongoing outbreak and forces an urgent need to improve antiviral therapeutics and targeted diagnosing tools. Researchers have been working to find a new drug to combat the virus since the outbreak started in late 2019, but there are currently no successful drugs to control the SARS-CoV-2, which makes the situation riskier. Very recently, new variant of SARS-CoV-2 is identified in many countries which make the situation very critical. No successful treatment has yet been shown although enormous international commitment to combat this pandemic and the start of different clinical trials. Nanomedicine has outstanding potential to solve several specific health issues, like viruses, which are regarded a significant medical issue. In this review, we presented an up-to-date drug design strategy against SARS-CoV-2, including the development of novel drugs and repurposed product potentials were useful, and successful drugs discovery is a constant requirement. The use of nanomaterials in treatment against SARS-CoV-2 and their use as carriers for the transport of the most frequently used antiviral therapeutics are discussed systematically here. We also addressed the possibilities of practical applications of nanoparticles to give the status of COVID-19 antiviral systems.
Competing Interests: Conflict of interestOn behalf of all authors, the corresponding authors state that there is no conflict of interest.
(© King Abdulaziz City for Science and Technology 2021.)
Databáze: MEDLINE
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