Evolution of COVID-19 Pregnancies Treated With Nitazoxanide in a Third-Level Hospital.

Autor:	Enríquez López KY; Department of Obstetrics and Gynaecology, 'Mónica Pretelini Sáenz' Maternal-Perinatal Hospital, Toluca, MEX., Meneses Calderón J; Department of Research, 'Mónica Pretelini Sáenz' Maternal-Perinatal Hospital, Toluca, MEX., de la Cruz Ávila L; Department of COVID, 'Mónica Pretelini Sáenz' Maternal-Perinatal Hospital, Toluca, MEX., López Esquivel MÁ; Department of Telemedicine, 'Mónica Pretelini Sáenz' Maternal-Perinatal Hospital, Toluca, MEX., Meneses Figueroa J; Laboratory of Genetics, Faculty of Medicine, Autonomous University of the State of Mexico, Toluca, MEX., Vargas Contreras MJ; Laboratory of Genetics, Faculty of Medicine, Autonomous University of the State of Mexico, Toluca, MEX., Anaya Herrera J; Department of Obstetrics and Gynaecology, 'Mónica Pretelini Sáenz' Maternal-Perinatal Hospital, Toluca, MEX., Sotelo Martínez OR; Research and Teaching Unit, 'Mónica Pretelini Sáenz' Maternal-Perinatal Hospital, Toluca, MEX., Mendoza López JA; Reseach and Teaching Unit, 'Mónica Pretelini Sáenz' Maternal-Perinatal Hospital, Toluca, MEX., Mendieta Zerón H; Faculty of Medicine, Autonomous University of the State of Mexico, Toluca, MEX.
Jazyk:	angličtina
Zdroj:	Cureus [Cureus] 2021 May 13; Vol. 13 (5), pp. e15002. Date of Electronic Publication: 2021 May 13.
DOI:	10.7759/cureus.15002
Abstrakt:	Background Nitazoxanide shows adequate in vitro activity against coronavirus. The aim of this study was to describe the behavior of coronavirus disease 2019 (COVID-19) in pregnant women treated with nitazoxanide. Methodology This cross-sectional study included the files of COVID-19 positive pregnant women treated with nitazoxanide 500 mg every 6 hours, levofloxacin every 12 hours, and clarithromycin 500 mg every 12 hours. Results The data of 51 women (mean age: 27.4 ± 7.2 years) were analyzed. Eleven (21.56%) patients had to receive medical attention in the intensive care unit. There were 22 (43.13%) preterm deliveries, 21 by cesarean and one by vaginal delivery. The medical attention of this population was as follows: 31 cesareans, five vaginal deliveries, nine still pregnant, two requiring manual vacuum aspiration, two ectopic pregnancies, one requiring curettage, and one requiring hysterotomy. There were seven (13.72%) cases of preeclampsia, and there were two (3.92%) deaths. Conclusion Nitazoxanide prescription could be an option against COVID-19 in pregnancy due to its safety profile. Competing Interests: The authors have declared that no competing interests exist. (Copyright © 2021, Enríquez López et al.)
Databáze:	MEDLINE
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