A case of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) presenting as post-infectious manifestation of SARS-CoV-2 infection.

Autor:	Rajendran I; Radiology fellow, Department of Radiology, Royal Oldham hospital, Pennine Acute NHS Foundation Trust, Oldham, United Kingdom., Natarajan MD; Consultant Radiologist, Department of Radiology, Royal Oldham hospital Pennine Acute NHS Foundation Trust, Oldham, United Kingdom., Narwani P; Radiology fellow, Department of Radiology, Royal Oldham hospital, Pennine Acute NHS Foundation Trust, Oldham, United Kingdom., Alzouabi O; Stroke physician. Stroke Unit. Fairfield General Hospital. Pennine Acute Hospital NHS Foundation Trust, Oldham, United Kingdom., Kawafi K; Clinical Director of stroke unit. Stroke Unit. Fairfield General Hospital. Pennine Acute Hospitals NHS Foundation Trust, Oldham, United Kingdom., Khanna N; Consultant Radiologist, Department of Radiology, Royal Oldham hospital. Pennine Acute NHS Foundation Trust, Oldham, United Kingdom.
Jazyk:	angličtina
Zdroj:	BJR case reports [BJR Case Rep] 2021 Apr 09; Vol. 7 (3), pp. 20210020. Date of Electronic Publication: 2021 Apr 09 (Print Publication: 2021).
DOI:	10.1259/bjrcr.20210020
Abstrakt:	White matter hyperintensities (WMHs) lacunar infarcts and cerebral microbleeds are well-established features associated with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). Increasing case reports and series recounts a wide array of neurological manifestations of COVID-19 including acute cerebrovascular disease, encephalopathy, encephalitis and demyelination. Recently association between COVID-19 and CADASIL has been identified. We describe an unusual case of CADASIL diagnosed as a possible post-infectious manifestation of COVID-19 patient with imaging features closely resembling post-infectious encephalomyelitis. Competing Interests: Competing Statement: At the time of diagnosis (April 2020), there were no published case reports. However, in the meantime, there are three case reports citing the association between CADASIL and COVID. But, there are a few unique features in this case which are: This is post-infectious manifestation of SARS CoV-2. Completely worked out with all relevant investigations. No known familial inheritance. The importance of this case is in establishing the wide neurological manifestations of SARS CoV-2 and in understanding the pathogenesis. The availability of this completely worked case in a reputed journal will make it available for wider data search and analysis. (© 2021 The Authors. Published by the British Institute of Radiology.)
Databáze:	MEDLINE
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