SARS-COV-2 infection outcomes in patients with congenital generalized lipodystrophy.

Autor: Madeira MP; Clinical Research Unit, Walter Cantidio University Hospital, Federal University of Ceará, Bloco das Ilhas - 1º Andar, Fortaleza, CE, 60430-270, Brazil.; Department of Clinical Medicine, Federal University of Ceará, Fortaleza, CE, Brazil., Freire EBL; Clinical Research Unit, Walter Cantidio University Hospital, Federal University of Ceará, Bloco das Ilhas - 1º Andar, Fortaleza, CE, 60430-270, Brazil.; Department of Clinical Medicine, Federal University of Ceará, Fortaleza, CE, Brazil., Fernandes VO; Clinical Research Unit, Walter Cantidio University Hospital, Federal University of Ceará, Bloco das Ilhas - 1º Andar, Fortaleza, CE, 60430-270, Brazil.; Department of Clinical Medicine, Federal University of Ceará, Fortaleza, CE, Brazil.; Department of Community Health, Federal University of Ceará, Fortaleza, CE, Brazil., Lima GEDCP; Clinical Research Unit, Walter Cantidio University Hospital, Federal University of Ceará, Bloco das Ilhas - 1º Andar, Fortaleza, CE, 60430-270, Brazil.; Department of Clinical Medicine, Federal University of Ceará, Fortaleza, CE, Brazil., Melo IDP; Clinical Research Unit, Walter Cantidio University Hospital, Federal University of Ceará, Bloco das Ilhas - 1º Andar, Fortaleza, CE, 60430-270, Brazil.; Department of Clinical Medicine, Federal University of Ceará, Fortaleza, CE, Brazil., Montenegro APDR; Clinical Research Unit, Walter Cantidio University Hospital, Federal University of Ceará, Bloco das Ilhas - 1º Andar, Fortaleza, CE, 60430-270, Brazil., Freire JEDC; Clinical Research Unit, Walter Cantidio University Hospital, Federal University of Ceará, Bloco das Ilhas - 1º Andar, Fortaleza, CE, 60430-270, Brazil.; Department of Clinical Medicine, Federal University of Ceará, Fortaleza, CE, Brazil., Moreira-Nunes CFA; Drug Research and Development Center (NPDM), Federal University of Ceará, Fortaleza, CE, Brazil., Montenegro RC; Department of Clinical Medicine, Federal University of Ceará, Fortaleza, CE, Brazil.; Drug Research and Development Center (NPDM), Federal University of Ceará, Fortaleza, CE, Brazil., Colares JKB; PostGraduate Program in Medical Sciences, University of Fortaleza, Fortaleza, CE, Brazil., Montenegro Junior RM; Clinical Research Unit, Walter Cantidio University Hospital, Federal University of Ceará, Bloco das Ilhas - 1º Andar, Fortaleza, CE, 60430-270, Brazil. renanmmjr@gmail.com.; Department of Clinical Medicine, Federal University of Ceará, Fortaleza, CE, Brazil. renanmmjr@gmail.com.; Department of Community Health, Federal University of Ceará, Fortaleza, CE, Brazil. renanmmjr@gmail.com.
Jazyk: angličtina
Zdroj: Diabetology & metabolic syndrome [Diabetol Metab Syndr] 2021 Jun 13; Vol. 13 (1), pp. 65. Date of Electronic Publication: 2021 Jun 13.
DOI: 10.1186/s13098-021-00680-1
Abstrakt: Background: A new strain of human coronavirus (HCoV) spread rapidly around the world. Diabetes and obesity are associated with a worse prognosis in these patients. Congenital Generalized Lipodystrophy (CGL) patients generally have poorly controlled diabetes and require extremely high doses of insulin. There is no documentation in the literature of cases of COVID in CGL patients. Thus, we aimed to evaluate the prevalence of SARS-CoV-2 infection in CGL patients, and the association of their clinical and metabolic characteristics and outcomes.
Methods: This is a cross-sectional study carried out between July and October 2020. Clinical data collected were respiratory or other flu-like symptoms, need of hospitalization in the last three months, CGL comorbidities, and medications in use. Cholesterol, triglycerides, glycohemoglobin A1c levels, anti-SARS-CoV-2 antibodies and nasopharyngeal swab for RT-qPCR were also obtained in all CGL patients. Mann-Whitney U test was used to analyze the characteristics of the participants, verifying the non-adherence of the data to the Gaussian distribution. In investigating the association between categorical variables, we used Pearson's chi-square test and Fisher's exact test. A significance level of 5% was adopted.
Results: Twenty-two CGL patients were assessed. Eight subjects (36.4%) had reactive anti-SARS-CoV-2 antibodies. Only one of these, also presented detectable RT-qPCR. Five individuals (62.5%) were women, median age of 13.5 years (1 to 37). Symptoms like fever, malaise, nausea, diarrhea and chest pain were present, and all asymptomatic patients were children. All subjects had inadequate metabolic control, with no difference between groups. Among positive individuals there was no difference between those with AGPAT2 (75%) and BSCL2 gene mutations (25%) (p > 0.05). No patient needed hospitalization or died.
Conclusions: We described a high prevalence of SARS-CoV-2 infection in CGL patients with a good outcome in all of them. These findings suggest that at least young CGL patients infected by SARS-COV-2 are not at higher risk of poor outcome, despite known severe metabolic comorbidities.
Databáze: MEDLINE
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