Clinical and echocardiographic findings in a cross-sectional study of HIV-infected adults in Enugu, Nigeria.

Autor: Njoku PO; Department of Medicine, University of Nigeria Teaching Hospital, Enugu, Nigeria. Email: passyokuchi18@gmail.com., Ejim EC; Department of Medicine, University of Nigeria Teaching Hospital, Enugu, Nigeria., Anisiuba BC; Department of Medicine, University of Nigeria Teaching Hospital, Enugu, Nigeria., Ike SO; Department of Medicine, University of Nigeria Teaching Hospital, Enugu, Nigeria., Onwubere BJ; Department of Medicine, University of Nigeria Teaching Hospital, Enugu, Nigeria.
Jazyk: angličtina
Zdroj: Cardiovascular journal of Africa [Cardiovasc J Afr] 2021 Nov-Dec 23; Vol. 32 (6), pp. 320-326. Date of Electronic Publication: 2021 May 12.
DOI: 10.5830/CVJA-2020-065
Abstrakt: Background: Human immunodeficiency virus (HIV) infection and highly active antiretroviral therapy (HAART) are implicated in cardiovascular diseases. The objective of this study was to evaluate the clinical and echocardiographic findings in HIV-infected adults.
Methods: One hundred HIV subjects on HAART, 100 HAART-naïve patients and 100 controls were recruited in this cross-sectional study.
Results: Mean CD4 cell count was significantly higher in the HAART-exposed (408.43 ± 221.62) than the HAART-naïve groups (250.06 ± 154.26) ( p < 0.001). Weight loss (49%), skin lesions (14%), body weakness (24%), oral thrush (10%) and lymphadenopathy (10%) were more prevalent in HAART-naïve patients ( p < 0.05). Dimensions of aortic root (2.71 cm), left atrium (3.27 cm) and left ventricular mass index (79.95) were significantly higher in HIV-positive subjects on HAART ( p < 0.05).
Conclusions: Clinical features of HIV and the CD4 nadir were more prevalent in the HIV-positive, HAART-naïve subjects. Dimensions of the aortic root, left atrium and left ventricle were relatively larger in the HAART-exposed patients while wall thickness and ejection fraction were higher in the HAART-naïve subjects.
Databáze: MEDLINE
Externí odkaz: