A multicentre point prevalence study of antibiotics utilization in hospitalized patients in an urban secondary and a tertiary healthcare facilities in Nigeria: findings and implications.

Autor:	Ogunleye OO; Department of Pharmacology, Therapeutics and Toxicology, Lagos State University College of Medicine, Ikeja, Lagos, Nigeria.; Department of Medicine, Lagos State University Teaching Hospital, Ikeja, Lagos, Nigeria., Oyawole MR; Department of Pharmacy, Lagos State University Teaching Hospital, Ikeja, Lagos, Nigeria., Odunuga PT; Department of Pharmacy, Lagos State University Teaching Hospital, Ikeja, Lagos, Nigeria., Kalejaye F; Department of Pharmacy, Lagos State University Teaching Hospital, Ikeja, Lagos, Nigeria., Yinka-Ogunleye AF; Nigerian Centre for Disease Control, Federal Capital Territory, Abuja, Nigeria.; Institute of Global Health, University College, London, UK., Olalekan A; Department of Medical Laboratory Science, University of Lagos, Idiaraba, Lagos, Nigeria.; Centre for Genomics of Non-Communicable Diseases and Personalized Healthcare (CGNPH), University of Lagos, Akoka, Lagos, Nigeria., Ogundele SO; Department of Pharmacology, Therapeutics and Toxicology, Lagos State University College of Medicine, Ikeja, Lagos, Nigeria.; Department of Medicine, Lagos State University Teaching Hospital, Ikeja, Lagos, Nigeria., Ebruke BE; International Foundation Against Infectious Diseases In Nigeria (IFAIN), Abuja, Nigeria., Kalada Richard A; Department of Medicine, General Hospital, Lagos, Nigeria., Anand Paramadhas BD; Department of Pharmacy, Nyangabgwe Hospital, Francistown, Botswana., Kurdi A; Strathclyde Institute of Pharmacy and Biomedical Sciences, Strathclyde University, Glasgow, UK.; Department of Pharmacology, College of Pharmacy, Hawler Medical University, Erbil, Iraq.; School of Pharmacy, Sefako Makgatho Health Sciences University, Pretoria, South Africa., Sneddon J; Healthcare Improvement Scotland, Delta House, Glasgow, UK., Seaton A; Healthcare Improvement Scotland, Delta House, Glasgow, UK.; Queen Elizabeth University Hospital, Glasgow, UK.; University of Glasgow, Glasgow, UK., Godman B; Strathclyde Institute of Pharmacy and Biomedical Sciences, Strathclyde University, Glasgow, UK.; School of Pharmacy, Sefako Makgatho Health Sciences University, Pretoria, South Africa.; School of Pharmaceutical Sciences, Universiti Sains Malaysia, Penang, Malaysia.
Jazyk:	angličtina
Zdroj:	Expert review of anti-infective therapy [Expert Rev Anti Infect Ther] 2022 Feb; Vol. 20 (2), pp. 297-306. Date of Electronic Publication: 2021 Jun 21.
DOI:	10.1080/14787210.2021.1941870
Abstrakt:	Objectives: The understanding of antimicrobial utilization patterns is pertinent to successful implementation of the National Action Plans on Antimicrobial Resistance (AMR). There is, however, limited information on antibiotics utilization in Nigeria. This study was undertaken to build on existing information and provide direction for appropriate interventions including Antibiotics Stewardship Programs (ASP). Method: A Point Prevalence Study (PPS) was conducted in two public urban health facilities in Lagos, Nigeria using a design adapted from the European Center for Disease Prevention and Control (ECDC) and Global-PPS surveys. Results: The prevalence of antibiotics use was 80.6% administered mostly parenterally (83.1% of total prescriptions) with concerns with extended surgical antibiotics prophylaxis. The mostly used antibiotics in the secondary hospital were parenteral metronidazole (32.4%), ceftriaxone (27.5%), and amoxicillin + clavulanate (8.2%) while the mostly used in the tertiary hospital were ceftriaxone (25.3%), parenteral metronidazole (19.1%), and amoxicillin + clavulanate (9.3%). There was an appreciable lack of specific functional capacities, policies, and processes to promote appropriate antimicrobial use in both hospitals. Conclusions: There is high rate of antibiotics utilization in these facilities with lack of institutional frameworks and processes for ensuring appropriate antibiotic use. The study provides the information needed to improve future antimicrobial use in hospitals and reduce AMR.
Databáze:	MEDLINE
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