| Autor: |
Marreiro DDN; Departament of Nutrition, Federal University of Piaui, Campus Minister Petrônio Portela, Teresina, PI, Brasil., Cruz KJC; Departament of Nutrition, Federal University of Piaui, Campus Minister Petrônio Portela, Teresina, PI, Brasil., Oliveira ARS; Departament of Nutrition, Federal University of Piaui, Campus Minister Petrônio Portela, Teresina, PI, Brasil., Morais JBS; Departament of Nutrition, Federal University of Piaui, Campus Minister Petrônio Portela, Teresina, PI, Brasil., Freitas BJESA; Departament of Nutrition, Federal University of Piaui, Campus Minister Petrônio Portela, Teresina, PI, Brasil., Melo SRS; Departament of Nutrition, Federal University of Piaui, Campus Minister Petrônio Portela, Teresina, PI, Brasil., Dos Santos LR; Departament of Nutrition, Federal University of Piaui, Campus Minister Petrônio Portela, Teresina, PI, Brasil., Cardoso BEP; Departament of Nutrition, Federal University of Piaui, Campus Minister Petrônio Portela, Teresina, PI, Brasil., Dias TMDS; Departament of Nutrition, Federal University of Piaui, Campus Minister Petrônio Portela, Teresina, PI, Brasil. |
| Abstrakt: |
Zn deficiency compromises its biological functions, its effect on the immune system and its antiviral activity, increasing vulnerability to infectious diseases. This narrative review aims at presenting and discussing functional aspects and possible mechanisms involved in the potential role of Zn in the immune response and antiviral activity for coronavirus infectious disease-19 (COVID-19) prevention and control. The searches were conducted in PubMed and Science Direct databases, using clinical trials, experimental studies in animals and humans, case-control studies, case series, letters to the editor, and review articles published in English, without restrictions on year of publication. Search approach was based on using the terms: 'zinc', 'COVID-19', 'antiviral agents', 'immunologic factors' and 'respiratory tract infections'. Literature shows the importance of Zn as an essential mineral immunomodulator with relevant antiviral activity in the body. Thus, although there is still a scarcity of studies evaluating Zn supplementation in patients with COVID-19, the results on the topic show the necessity of controlling Zn mineral deficiency, as well as maintaining its homoeostasis in the body in order to strengthen the immune system and improve the prevention of highly complex viral infections, such as that of the COVID-19. |
