Frequency of post treatment control varies by antiretroviral therapy restart and viral load criteria.

Autor:	Fajnzylber J; Brigham and Women's Hospital, Harvard Medical School., Sharaf R; Brigham and Women's Hospital, Harvard Medical School., Hutchinson JN; Harvard T.H. Chan School of Public Health, Boston, Massachusetts., Aga E; Harvard T.H. Chan School of Public Health, Boston, Massachusetts., Bosch RJ; Harvard T.H. Chan School of Public Health, Boston, Massachusetts., Hartogensis W; University of California, San Francisco, San Francisco, California., Jacobson JM; Case Western Reserve University, Cleveland, Ohio., Connick E; University of Arizona, Tucson, Arizona., Volberding P; University of California, San Francisco, San Francisco, California., Skiest DJ; University of Massachusetts-Baystate, Springfield, Massachusetts., Margolis D; University of North Carolina, Chapel Hill, North Carolina., Sneller MC; National Institute of Allergy and Infectious Diseases, Bethesda, Maryland., Little SJ; University of Caliornia, San Diego, San Diego, California., Gulick RM; Weill Cornell Medicine, New York, New York., Mellors JW; University of Pittsburgh, Pittsburgh, Pennsylvania., Gandhi RT; Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Schooley RT; University of Caliornia, San Diego, San Diego, California., Henry K; University of Minnesota, Minneapolis, Minnesota., Tebas P; University of Pennsylvania, Philadelphia, Pennsylvania., Deeks S; University of California, San Francisco, San Francisco, California., Chun TW; National Institute of Allergy and Infectious Diseases, Bethesda, Maryland., Collier AC; University of Washington, Seattle, Washington, USA., Hecht FM; University of California, San Francisco, San Francisco, California., Li JZ; Brigham and Women's Hospital, Harvard Medical School.
Jazyk:	angličtina
Zdroj:	AIDS (London, England) [AIDS] 2021 Nov 01; Vol. 35 (13), pp. 2225-2227.
DOI:	10.1097/QAD.0000000000002978
Abstrakt:	Clinical trials including an analytical treatment interruption (ATI) are vital for evaluating the efficacy of novel strategies for HIV remissions. We briefly describe an interactive tool for predicting viral rebound timing in ATI trials and the impact of posttreatment controller (PTC) definitions on PTC frequency estimates. A 4-week viral load threshold of 1000 cps/ml provides both high specificity and sensitivity for PTC detection. PTC frequency varies greatly based on the definition of a PTC. (Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.)
Databáze:	MEDLINE
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