Defining the Molecular Hallmarks of T-Cell Memory.
| Autor: | Zebley CC; Bone Marrow Transplant and Cellular Therapy, St. Jude Children's Research Hospital, Memphis, Tennessee 38105-3678, USA., Akondy RS; Division of Infectious Diseases, Emory University School of Medicine, Atlanta, Georgia 30322, USA., Youngblood BA; Immunology Department, St. Jude Children's Research Hospital, Memphis, Tennessee 38105-3678, USA., Kissick HT; Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia 30322, USA. |
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| Jazyk: | angličtina |
| Zdroj: | Cold Spring Harbor perspectives in biology [Cold Spring Harb Perspect Biol] 2022 Mar 01; Vol. 14 (3). Date of Electronic Publication: 2022 Mar 01. |
| DOI: | 10.1101/cshperspect.a037804 |
| Abstrakt: | The pool of memory CD8 T cells is comprised of highly specialized subpopulations of cells with both shared and distinct functions. The ongoing study of T-cell memory is focused on how these different subpopulations arise, how the cells are maintained over the life of the host, and how the cells protect a host against reinfection. As a field we have used the convenience of a narrow range of surface markers to define and study these memory T-cell subsets. However, as we learn more about these cells, it is becoming clear that these broad definitions are insufficient to capture the complexity of the CD8 memory T-cell pool, and an updated definition of these cellular states are needed. Here, we discuss data that have recently arisen that highlight the difficulty in using surface markers to functionally characterize CD8 T-cell populations, and the possibility of using the epigenetic state of cells to more clearly define the functional capacity of CD8 memory T-cell subsets. (Copyright © 2022 Cold Spring Harbor Laboratory Press; all rights reserved.) |
| Databáze: | MEDLINE |
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