Interaction between the pulmonary stretch receptor and pontine control of expiratory duration.

Autor: Zuperku EJ; Clement J. Zablocki Department of Veterans Affairs Medical Center, Milwaukee, WI, 53295 USA; Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, WI, 53226, USA. Electronic address: ezuperku@mcw.edu., Hopp FA; Clement J. Zablocki Department of Veterans Affairs Medical Center, Milwaukee, WI, 53295 USA. Electronic address: fhopp@mcw.edu., Stuth EAE; Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, WI, 53226, USA; Pediatric Anesthesia, Children's Hospital of Wisconsin, Milwaukee, WI, 53226, USA. Electronic address: estuth@mcw.edu., Stucke AG; Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, WI, 53226, USA; Pediatric Anesthesia, Children's Hospital of Wisconsin, Milwaukee, WI, 53226, USA. Electronic address: astucke@mcw.edu.
Jazyk: angličtina
Zdroj: Respiratory physiology & neurobiology [Respir Physiol Neurobiol] 2021 Nov; Vol. 293, pp. 103715. Date of Electronic Publication: 2021 Jun 11.
DOI: 10.1016/j.resp.2021.103715
Abstrakt: Medial parabrachial nucleus (mPBN) neuronal activity plays a key role in controlling expiratory (E)-duration (TE). Pulmonary stretch receptor (PSR) activity during the E-phase prolongs TE. The aims of this study were to characterize the interaction between the PSR and mPBN control of TE and underlying mechanisms. Decerebrated mechanically ventilated dogs were studied. The mPBN subregion was activated by electrical stimulation via bipolar microelectrode. PSR afferents were activated by low-level currents applied to the transected central vagus nerve. Both stimulus-frequency patterns during the E-phase were synchronized to the phrenic neurogram; TE was measured. A functional mathematical model for the control of TE and extracellular recordings from neurons in the preBötzinger/Bötzinger complex (preBC/BC) were used to understand mechanisms. Findings show that the mPBN gain-modulates, via attenuation, the PSR-mediated reflex. The model suggested functional sites for attenuation and neuronal data suggested correlates. The PSR- and PB-inputs appear to interact on E-decrementing neurons, which synaptically inhibit pre-I neurons, delaying the onset of the next I-phase.
(Published by Elsevier B.V.)
Databáze: MEDLINE
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