Molecular Mechanisms of Chondrocyte Proliferation and Differentiation.

Autor:	Chen H; Hunan University of Chinese Medicine & Hunan Academy of Chinese Medicine, Changsha, China.; The Affiliated Hospital of Hunan Academy of Chinese Medicine, Changsha, China.; Department of Pharmaceutical Engineering, School of Chemical Engineering, Xiangtan University, Xiangtan, China., Tan XN; Hunan University of Chinese Medicine & Hunan Academy of Chinese Medicine, Changsha, China.; The Affiliated Hospital of Hunan Academy of Chinese Medicine, Changsha, China., Hu S; Department of Pharmaceutical Engineering, School of Chemical Engineering, Xiangtan University, Xiangtan, China.; Center for Bionic Sensing and Intelligence, Institute of Bio-medical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China., Liu RQ; Hunan University of Chinese Medicine & Hunan Academy of Chinese Medicine, Changsha, China.; The Affiliated Hospital of Hunan Academy of Chinese Medicine, Changsha, China.; Department of Pharmaceutical Engineering, School of Chemical Engineering, Xiangtan University, Xiangtan, China., Peng LH; School of Computer, Hunan University of Technology, Zhuzhou, China., Li YM; Hunan University of Chinese Medicine & Hunan Academy of Chinese Medicine, Changsha, China.; The Affiliated Hospital of Hunan Academy of Chinese Medicine, Changsha, China., Wu P; Hunan University of Chinese Medicine & Hunan Academy of Chinese Medicine, Changsha, China.; The Affiliated Hospital of Hunan Academy of Chinese Medicine, Changsha, China.; Department of Pharmaceutical Engineering, School of Chemical Engineering, Xiangtan University, Xiangtan, China.
Jazyk:	angličtina
Zdroj:	Frontiers in cell and developmental biology [Front Cell Dev Biol] 2021 May 28; Vol. 9, pp. 664168. Date of Electronic Publication: 2021 May 28 (Print Publication: 2021).
DOI:	10.3389/fcell.2021.664168
Abstrakt:	Cartilage is a kind of connective tissue that buffers pressure and is essential to protect joint movement. It is difficult to self-recover once cartilage is damaged due to the lack of blood vessels, lymph, and nerve tissues. Repair of cartilage injury is mainly achieved by stimulating chondrocyte proliferation and extracellular matrix (ECM) synthesis. Cartilage homeostasis involves the regulation of multiple growth factors and the transduction of cellular signals. It is a very complicated process that has not been elucidated in detail. In this review, we summarized a variety of signaling molecules related to chondrocytes function. Especially, we described the correlation between chondrocyte-specific regulatory factors and cell signaling molecules. It has potential significance for guiding the treatment of cartilage injury. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2021 Chen, Tan, Hu, Liu, Peng, Li and Wu.)
Databáze:	MEDLINE
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