Risk of Birth Defects From Vitamin A "Acne Supplements" Sold Online.
| Autor: | Zamil DH; Baylor College of Medicine, Houston, Texas, USA., Burns EK; Baylor College of Medicine, Houston, Texas, USA., Perez-Sanchez A; Department of Internal Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA., Parke MA; Baylor College of Medicine, Houston, Texas, USA., Katta R; McGovern Medical School at University of Texas Health Science Center at Houston, Houston, Texas, USA. |
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| Jazyk: | angličtina |
| Zdroj: | Dermatology practical & conceptual [Dermatol Pract Concept] 2021 May 20; Vol. 11 (3), pp. e2021075. Date of Electronic Publication: 2021 May 20 (Print Publication: 2021). |
| DOI: | 10.5826/dpc.1103a75 |
| Abstrakt: | Background: Dietary supplements are popular among US consumers and claim to address a variety of conditions, including acne. Acne supplements containing vitamin A are of particular interest, due to the potentially teratogenic effects of vitamin A doses over 10,000 IU. Objective: This study examined dosage, pregnancy risks, and labeling of vitamin A-containing acne supplements available online. Methods: An Internet search of acne supplements sold online was conducted between March and May 2020. Supplement labels and websites were analyzed for vitamin A content and pregnancy warnings, and then divided into categories based on dosage and teratogenic risk. Results: A total of 49 acne supplements was found, and of these 26 (53%) contain vitamin A. Three supplements are likely teratogenic, 4 contain vitamin A doses exceeding the daily level of intake that meets the nutritional needs of most people, and 15 have an unknown teratogenic risk. Among the 6 supplements with over 10,000 IU vitamin A, 2 have no pregnancy warning at all, including the supplement with the highest vitamin A dose found in this study. Conclusions: Dietary supplements are not subject to the same stringent regulations as drugs, and as such, consumers may be unaware of pregnancy risks. Furthermore, FDA requirements on labeling of vitamin A supplements may lead to consumer confusion regarding dosage. As such, we encourage stricter labeling requirements for vitamin A-containing supplements, including pregnancy warnings for high-dose supplements and clearer dosage labeling. Competing Interests: Competing interests statement: Rajani Katta, MD, serves on an advisory board for Vichy Laboratories and is the author of a book on diet and dermatology for the general public. The other authors have no conflicts of interest to disclose. (©2021 Zamil et al.) |
| Databáze: | MEDLINE |
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