Raman spectroscopy for guidance of vulvar cancer surgery: a pilot study.
| Autor: | van Doorn HC; Department of Gynaecologic Oncology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.; shared first authorship., Barroso EM; Department of Pathology, Erasmus MC, Erasmus University Medical Center, Rotterdam, The Netherlands.; shared first authorship., Koljenović S; Department of Pathology, Erasmus MC, Erasmus University Medical Center, Rotterdam, The Netherlands., Ewing-Graham PC; Department of Pathology, Erasmus MC, Erasmus University Medical Center, Rotterdam, The Netherlands., Soares MRN; Department of Pathology, Erasmus MC, Erasmus University Medical Center, Rotterdam, The Netherlands., van de Berg NJ; Department of Gynaecologic Oncology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands., Schut TCB; Department of Dermatology, Erasmus MC, Erasmus University Medical Center, Rotterdam, The Netherlands., Puppels GJ; Department of Dermatology, Erasmus MC, Erasmus University Medical Center, Rotterdam, The Netherlands. |
|---|---|
| Jazyk: | angličtina |
| Zdroj: | Biomedical optics express [Biomed Opt Express] 2021 Apr 28; Vol. 12 (5), pp. 3008-3020. Date of Electronic Publication: 2021 Apr 28 (Print Publication: 2021). |
| DOI: | 10.1364/BOE.420882 |
| Abstrakt: | For vulvar squamous cell carcinoma (VSCC), the mainstay of treatment is surgical removal with tumour-free margins. Surgeons still operate without objective tools that provide margin-status. This study assesses Raman spectroscopy potentiality for distinguishing ex-vivo VSCC from healthy tissue in 11 patients. Grid-based Raman maps were obtained from processed spectra. Water content and C-H band ratio (2,910-2,966 cm -1 / 2810-2890 cm -1 ) were calculated per spectrum and used as linear discriminant parameters. Healthy tissue was differentiated from VSCC with 0.90 discriminative power, 0.79 sensitivity and 0.86 specificity.This is an important step towards the development of objective tools for VSCC surgical guidance. Competing Interests: S. Koljenović, and G.J. Puppels have ownership interest (including patents) in RiverD International BV. T.C. Bakker Schut, M. Rosa N. Soares are employees of RiverD International BV. M. Rosa N. Soares is also employee of RiverD International BV. G.J. Puppels is employed with RiverD International BV as a CTO & Managing Director. No potential conflicts of interest were disclosed by the other authors. (© 2021 Optical Society of America under the terms of the OSA Open Access Publishing Agreement.) |
| Databáze: | MEDLINE |
| Externí odkaz: |
|