Dandelion flower-like micelles.
| Autor: | Yao Y; National Engineering Research Center for Biomaterials, Sichuan University 29 Wangjiang Road Chengdu 610064 China szhang@scu.edu.cn., Xu D; College of Chemistry and Environmental Protection Engineering, Southwest Minzu University Chengdu 610041 China luojb1971@163.com.; Sichuan Guojian Inspection Co., Ltd. 646000 Luzhou Sichuan China., Zhu Y; National Engineering Research Center for Biomaterials, Sichuan University 29 Wangjiang Road Chengdu 610064 China szhang@scu.edu.cn., Dai X; National Engineering Research Center for Biomaterials, Sichuan University 29 Wangjiang Road Chengdu 610064 China szhang@scu.edu.cn., Yu Y; National Engineering Research Center for Biomaterials, Sichuan University 29 Wangjiang Road Chengdu 610064 China szhang@scu.edu.cn., Luo J; College of Chemistry and Environmental Protection Engineering, Southwest Minzu University Chengdu 610041 China luojb1971@163.com., Zhang S; National Engineering Research Center for Biomaterials, Sichuan University 29 Wangjiang Road Chengdu 610064 China szhang@scu.edu.cn. |
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| Jazyk: | angličtina |
| Zdroj: | Chemical science [Chem Sci] 2019 Dec 03; Vol. 11 (3), pp. 757-762. Date of Electronic Publication: 2019 Dec 03. |
| DOI: | 10.1039/c9sc05741b |
| Abstrakt: | Dandelion flower-like micelles (DFMs) were prepared by self-assembly of polycaprolactone (PCL) functionalized surface cross-linked micelles (SCMs). Upon reductive stimuli, the SCMs can be released from the DFMs by non-Brownian motion at an average speed of 19.09 μm s -1 . Similar to the property of dandelion flowers dispersing their seeds over a long distance, the DFMs demonstrated enhanced multicellular tumor spheroid (MTS) penetration, a useful property in the treatment of many diseases including cancer, infection-of-biofilm diseases and ocular problems. Competing Interests: There are no conflicts to declare. (This journal is © The Royal Society of Chemistry.) |
| Databáze: | MEDLINE |
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