| Autor: |
Dos Santos JDM; Graduate Program in Physical Education, Federal University of Sergipe, São Cristóvão, SE, BRAZIL., Aidar FJ; Graduate Program in Physical Education, Federal University of Sergipe, São Cristóvão, SE, BRAZIL.; Graduate Program in Physiological Sciences, Federal University of Sergipe, São Cristóvão, SE, BRAZIL.; Group of Studies and Research of Performance, Sport, Health and Paralympic Sports-GEPEPS, Federal University of Sergipe, São Cristovão, Sergipe, BRAZIL., DE Matos DG; Group of Studies and Research of Performance, Sport, Health and Paralympic Sports-GEPEPS, Federal University of Sergipe, São Cristovão, Sergipe, BRAZIL., DE Oliveira JU; Graduate Program in Physical Education, Federal University of Sergipe, São Cristóvão, SE, BRAZIL.; Group of Studies and Research of Performance, Sport, Health and Paralympic Sports-GEPEPS, Federal University of Sergipe, São Cristovão, Sergipe, BRAZIL., Júnior ASS; Graduate Program in Physical Education, Federal University of Sergipe, São Cristóvão, SE, BRAZIL., Dos Santos JL; Graduate Program in Physical Education, Federal University of Sergipe, São Cristóvão, SE, BRAZIL.; Program in Biotechnology, Northeast Network in Biotechnology (RENORBIO), Federal University of Sergipe, Sergipe, BRAZIL.; Laboratory of Natural Product Chemistry and Biochemistry, Department of Physiology, Federal University of Sergipe, Sergipe, BRAZIL., Marçal AC; Graduate Program in Physical Education, Federal University of Sergipe, São Cristóvão, SE, BRAZIL.; Department of Morphology, Federal University of Sergipe, Sergipe, BRAZIL., DE Araújo SS; Laboratory of Natural Product Chemistry and Biochemistry, Department of Physiology, Federal University of Sergipe, Sergipe, BRAZIL. |
| Abstrakt: |
We aimed to analyze the effects of long high-intensity interval training (HIIT) associated with pyridoxin supplementation on tissue and oxidative injury markers in animals. Male Wistar rats were divided into three groups (n = 8): sedentary (GS), HIIT (GH), and HIIT + pyridoxine (GHP). The HIIT comprised 18 sessions of 7 repetitions of 2min × 2min rest, 3 times per week. Pyridoxine was administered to the GHP group 1h before the exercise. The Thiobarbituric acid reactive substances (TBARS) and sulfhydryl group (SH) were analyzed as markers of oxidative stress and CK, LDH, ALT and AST as tissue lesions. There was an increase in the correlation between CK and LDH of 172.86% and 268.83% in the GH group compared with the GS group, respectively. There was a reduction in CK (34.37%) and LDH (34.74%) compared with the GH group, which had an increase of 229.03% in ALT. Pyridoxine supplementation reduced ALT by 80.62% in the GHP group compared with no-supplementation GH group. In addition, there was a reduction in plasma MDA (52.92%), liver (20.30%) and cardiac (22.06%) tissues in GHP compared to GH. It was possible to conclude that administration of pyridoxine attenuated oxidative stress, and tissue injuries induced by HIIT. |
