| Autor: |
Yi W; Department of Gynecology and Obstetrics, Beijing Ditan Hospital, Capital Medical University, Beijing, China., Cao X; Department of Gynecology and Obstetrics, Beijing Ditan Hospital, Capital Medical University, Beijing, China., Zeng Z; Department of Hepatology Division 2, Peking University Ditan Teaching Hospital, Beijing, China., Cao W; Department of Hepatology Division 2, Peking University Ditan Teaching Hospital, Beijing, China., Zhang Y; Department of Hepatology Division 2, Beijing Ditan Hospital, Capital Medical University, Beijing, China., Sun F; Department of Hepatology Division 2, Beijing Ditan Hospital, Capital Medical University, Beijing, China., Wang Y; Department of Child Health Care, Beijing Children's Hospital, Capital Medical University, Beijing, China., Wan G; Medical Records and Statistics Room, Beijing Ditan Hospital, Capital Medical University, Beijing, China., Li M; Department of Hepatology Division 2, Peking University Ditan Teaching Hospital, Beijing, China.; Department of Hepatology Division 2, Beijing Ditan Hospital, Capital Medical University, Beijing, China., Xie Y; Department of Hepatology Division 2, Peking University Ditan Teaching Hospital, Beijing, China.; Department of Hepatology Division 2, Beijing Ditan Hospital, Capital Medical University, Beijing, China. |
| Abstrakt: |
We prospectively investigated the neurological development in infants born from mothers treated with telbivudine (LdT) in the third trimester for prevention of hepatitis B virus (HBV) mother-to-infant transmission. Mothers with high HBV load were assigned to either the LdT group ( n = 81, 600 mg of LdT each day from gestational week 28 to delivery) or the Control group ( n = 39, untreated). Their infants were followed for 36 months to assess physical and neurological developments with Gesell Developmental Schedule tools. At 12 months after birth, the mean scores in the LdT group for gross motor, fine motor, adaptive, linguistic, and personal social domains were similar to those in the Control group. At 36 months, infants in the LdT group had higher mean scores for gross motor than the Control group (98.42 ± 9.69 vs. 94.54 ± 7.48, P = 0.03). In the LdT group, the rates of normal development were higher for gross motor (96.30% vs. 82.05% P = 0.01) and lower for adaptive (74.07% vs. 92.31% P = 0.02). Multivariate regression analyses showed that exposure to LdT during pregnancy was independently associated with infant's development in gross motor (OR 6.49, 95% CI 1.37-30.20, P = 0.02) and adaptive (OR 0.18, 95% CI 0.05-0.71, P = 0.01) at 36 months. These results suggest that prenatal LdT exposure might affect neurological development in long-term observation.Abbreviations: LdT: telbivudine; HBV: hepatitis B virus; HBsAg: hepatitis B surface antigen; HBeAg: hepatitis Be antigen; HbsAb: hepatitis B surface antibody; ALT: alanine aminotransferase; NA: nucleoside/nucleotide analog; LAM: lamivudine; MTCT: mother-to-child transmission; GDS: Gesell Developmental Schedule; OR: odds ratio; CI: confidence interval; DQ: developmental quotient; RMB: renminbi; BMI: body mass Index; HBIG: hepatitis B immunoglobulin. |
