Pertussis seroprevalence among adults of reproductive age (20-39 years) in fourteen European countries.

Autor: Wehlin L; The Public Health Agency of Sweden, Solna, Sweden., Ljungman M; The Public Health Agency of Sweden, Solna, Sweden., Kühlmann-Berenzon S; The Public Health Agency of Sweden, Solna, Sweden., Galanis I; The Public Health Agency of Sweden, Solna, Sweden., Huygen K; Scientific Institute of Public Health (Sciensano, WIV-ISP), Brussels, Belgium., Pierard D; Ziekenhuis Brussel, Brussels, Belgium., Dalby T; Statens Serum Institut, Copenhagen, Denmark., Petridou E; Serology - Microbiology Department, 'Aghia Sophia', Athens Children's Hospital, Athens, Greece., Molnár Z; National Center for Epidemiology, Budapest, Hungary., Carollo M; Core Facilities Technical Scientific Service, Istituto Superiore di Sanità, Rome, Italy., Ausiello CM; Core Facilities Technical Scientific Service, Istituto Superiore di Sanità, Rome, Italy., Lipnickiene V; National Public Health Surveillance Laboratory, Vilnius, Lithuania., Haider J; Pathology Laboratorie, Pathology Department, Mater Dei Hospital, Valetta, Malta., Aase A; The Norwegian Institute of Public Health, Oslo, Norway., Herstad TK; The Norwegian Institute of Public Health, Oslo, Norway., Rastawicki W; National Institute of Public Health-National Institute of Hygiene, Warsaw, Poland., Rio C; National Institute of Health, Dr. Ricardo Jorge, Lisbon, Portugal., Popovici O; National Institute of Public Health, Bucharest, Romania., De Ory Manchon F; Centro Nacional de Microbiología, Instituto de Salud Carlos III, Madrid, Spain., Bacci S; European Centre for Disease Prevention and Control, Solna, Sweden., Barkoff AM; University of Turku, Turku, Finland., Hänninen A; University of Turku, Turku, Finland.; Turku University Hospital, Turku, Finland., He Q; University of Turku, Turku, Finland.; Capital Medical University, Beijing, China., Hallander H; The Public Health Agency of Sweden, Solna, Sweden.
Jazyk: angličtina
Zdroj: APMIS : acta pathologica, microbiologica, et immunologica Scandinavica [APMIS] 2021 Sep; Vol. 129 (9), pp. 556-565. Date of Electronic Publication: 2021 Jul 01.
DOI: 10.1111/apm.13165
Abstrakt: The reported incidence of pertussis in European countries varies considerably. We aimed to study specific Bordetella pertussis seroprevalence in Europe by measuring serum IgG antibody levels to pertussis toxin (anti-PT IgG). Fourteen national laboratories participated in this study including Belgium, Denmark, Finland, Greece, Hungary, Italy, Lithuania, Malta, Norway, Poland, Portugal, Romania, Spain, and Sweden. Each country collected approximately 250 samples (N = 7903) from the age groups 20-29 years (N = 3976) and 30-39 years (N = 3927) during 2010-2013. Samples were anonymous residual sera from diagnostic laboratories and were analyzed at the national laboratories by a Swedish reference method, a commercial ELISA kit, or were sent to Sweden for analysis. The median anti-PT IgG concentrations ranged from 4 to 13.6 IU/mL. The proportion of samples with anti-PT IgG ≥100 IU/mL, indicating a recent infection ranged from 0.2% (Hungary) to 5.7% (Portugal). The highest proportion of sera with anti-PT IgG levels between 50 and <100 IU/mL, indicating an infection within the last few years, was found in Portugal (12.3%) and Italy (13.9%). This study shows that the circulation of B. pertussis is quite extensive in adults, aged 20-39 years, despite well-established vaccination programs in Europe.
(© 2021 APMIS. Published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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