A Review of Aflibercept Treatment for Macular Disease.

Autor: Anguita R; National Institute of Health Research Biomedical Research Centre at Moorfields Eye Hospital and UCL Institute of Ophthalmology, London, UK., Tasiopoulou A; National Institute of Health Research Biomedical Research Centre at Moorfields Eye Hospital and UCL Institute of Ophthalmology, London, UK.; Royal Devon and Exeter Hospital, Exeter, UK., Shahid S; National Institute of Health Research Biomedical Research Centre at Moorfields Eye Hospital and UCL Institute of Ophthalmology, London, UK., Roth J; National Institute of Health Research Biomedical Research Centre at Moorfields Eye Hospital and UCL Institute of Ophthalmology, London, UK., Sim SY; National Institute of Health Research Biomedical Research Centre at Moorfields Eye Hospital and UCL Institute of Ophthalmology, London, UK., Patel PJ; National Institute of Health Research Biomedical Research Centre at Moorfields Eye Hospital and UCL Institute of Ophthalmology, London, UK. praveen.patel1@nhs.net.
Jazyk: angličtina
Zdroj: Ophthalmology and therapy [Ophthalmol Ther] 2021 Sep; Vol. 10 (3), pp. 413-428. Date of Electronic Publication: 2021 Jun 13.
DOI: 10.1007/s40123-021-00354-1
Abstrakt: Aflibercept is a fully human recombinant fusion protein that includes the second domain of human VEGF receptor 1 and the third domain of human VEGF receptor 2. Despite the important role played by VEGF in maintaining the physiological condition of the retina under normal conditions, dysregulation of VEGF can result in pathological alterations including hyperpermeability of the retinal capillaries and migration and proliferation of retinal endothelial cells. Over the years, a number of studies have evaluated the use of intravitreal aflibercept in different retinal diseases. In this review, we aim to summarize the scientific evidence and recommendations for use of intravitreal aflibercept in neovascular age-related macular degeneration, diabetic macular oedema, macular oedema associated with retinal vein occlusion, and myopic choroidal neovascularization.
(© 2021. The Author(s).)
Databáze: MEDLINE
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