RUBIC (ReproUnion Biobank and Infertility Cohort): A binational clinical foundation to study risk factors, life course, and treatment of infertility and infertility-related morbidity.

Autor:	Priskorn L; Department of Growth and Reproduction, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark., Tøttenborg SS; Department of Occupational and Environmental Health, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark., Almstrup K; Department of Growth and Reproduction, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark., Andersson AM; Department of Growth and Reproduction, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark., Axelsson J; Reproductive Medicine Center, Skåne University Hospital, Malmö, Sweden., Bräuner EV; Department of Growth and Reproduction, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark., Elenkov A; Reproductive Medicine Center, Skåne University Hospital, Malmö, Sweden., Freiesleben NC; The Fertility Clinic, Copenhagen University Hospital - Amager and Hvidovre, Copenhagen, Denmark.; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark., Giwercman YL; Department of Translational Medicine, Lund University, Malmö, Sweden., Grøndahl ML; Fertility Clinic, Copenhagen University Hospital - Herlev and Gentofte, Copenhagen, Denmark., Hansen AH; Department of Growth and Reproduction, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark., Hansen LS; Department of Growth and Reproduction, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark., Henic E; Reproductive Medicine Center, Skåne University Hospital, Malmö, Sweden., Kitlinski ML; Reproductive Medicine Center, Skåne University Hospital, Malmö, Sweden., Landersoe SK; Fertility Department, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.; Department of Obstetrics and Gynecology, Copenhagen University Hospital - Amager and Hvidovre, Copenhagen, Denmark., Lindh C; Division of Occupational and Environmental Medicine, Lund University, Lund, Sweden., Løkkegaard EL; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.; Department of Obstetrics and Gynecology, Copenhagen University Hospital - North Zealand, Copenhagen, Denmark., Malm J; Department of Translational Medicine, Lund University, Malmö, Sweden., Olsen KW; Fertility Department, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark., Petersen KU; Department of Occupational and Environmental Health, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark., Schmidt L; Department of Public Health, University of Copenhagen, Copenhagen, Denmark., Stormlund S; Fertility Department, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark., Svendsen PF; Fertility Clinic, Copenhagen University Hospital - Herlev and Gentofte, Copenhagen, Denmark., Vassard D; Department of Public Health, University of Copenhagen, Copenhagen, Denmark., Wang NF; Fertility Department, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark., Zedeler A; Fertility Department, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark., Bhasin S; Research Program in Men's Health: Aging and Metabolism, Boston Claude D. Pepper Older Americans Independence Center, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA., Chavarro J; Departments of Nutrition and Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA., Eisenberg ML; Department of Urology and Obstetrics & Gynecology, Stanford University School of Medicine, Stanford, California, USA., Hauser R; Departments of Environmental Health and Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA., Huhtaniemi I; Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, London, UK., Krawetz SA; Department of Obstetrics and Gynecology, Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, Michigan, USA., Marko-Varga G; Department of Biomedical Engineering, Lund University, Lund, Sweden., Salonia A; Graduate School of Urology, University Vita-Salute San Raffaele, Milan, Italy.; Division of Experimental Oncology/Unit of Urology, URI, IRCCS Ospedale San Raffaele, Milan, Italy., Toppari J; Institute of Biomedicine, Research Centre for Integrated Physiology and Pharmacology, University of Turku, Turku, Finland.; Centre for Population Health Research, University of Turku, Turku, Finland.; Department of Pediatrics, Turku University Hospital, Turku, Finland., Juul A; Department of Growth and Reproduction, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark., Jørgensen N; Department of Growth and Reproduction, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark., Nielsen HS; The Fertility Clinic, Copenhagen University Hospital - Amager and Hvidovre, Copenhagen, Denmark.; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark., Pinborg A; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.; Fertility Department, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark., Rylander L; Division of Occupational and Environmental Medicine, Lund University, Lund, Sweden., Giwercman A; Reproductive Medicine Center, Skåne University Hospital, Malmö, Sweden.; Department of Translational Medicine, Lund University, Malmö, Sweden.
Jazyk:	angličtina
Zdroj:	Andrology [Andrology] 2021 Nov; Vol. 9 (6), pp. 1828-1842. Date of Electronic Publication: 2021 Jun 18.
DOI:	10.1111/andr.13063
Abstrakt:	Background: Infertility affects 15%-25% of all couples during their reproductive life span. It is a significant societal and public health problem with potential psychological, social, and economic consequences. Furthermore, infertility has been linked to adverse long-term health outcomes. Despite the advanced diagnostic and therapeutic techniques available, approximately 30% of infertile couples do not obtain a live birth after fertility treatment. For these couples, there are no further options to increase their chances of a successful pregnancy and live birth. Objectives: Three overall questions will be studied: (1) What are the risk factors and natural life courses of infertility, early embryonic loss, and adverse pregnancy outcomes? (2) Can we develop new diagnostic and prognostic biomarkers for fecundity and treatment success? And (3) what are the health characteristics of women and men in infertile couples at the time of fertility treatment and during long-term follow-up? Material and Methods: ReproUnion Biobank and Infertility Cohort (RUBIC) is established as an add-on to the routine fertility management at Copenhagen University Hospital Departments in the Capital Region of Denmark and Reproductive Medicine Centre at Skåne University Hospital in Sweden. The aim is to include a total of 5000 couples equally distributed between Denmark and Sweden. The first patients were enrolled in June 2020. All eligible infertile couples are prospectively asked to participate in the project. Participants complete an extensive questionnaire and undergo a physical examination and collection of biospecimens (blood, urine, hair, saliva, rectal swabs, feces, semen, endometrial biopsies, and vaginal swabs). After the cohort is established, the couples will be linked to the Danish and Swedish national registers to obtain information on parental, perinatal, childhood, and adult life histories, including disease and medication history. This will enable us to understand the causes of infertility and identify novel therapeutic options for this important societal problem. (© 2021 American Society of Andrology and European Academy of Andrology.)
Databáze:	MEDLINE
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