Ventricle contact may be associated with higher 11C methionine PET uptake in glioblastoma.

Autor: van Dijken BRJ; Department of Radiology, Medical Imaging Center (MIC), University Medical Center Groningen, P.O. Box 30.001, 9700 RB, Groningen, The Netherlands. b.r.j.van.dijken@umcg.nl., Schuuring B; Department of Radiology, Medical Imaging Center (MIC), University Medical Center Groningen, P.O. Box 30.001, 9700 RB, Groningen, The Netherlands., Jeltema HR; Department of Neurosurgery, University Medical Center Groningen, Groningen, The Netherlands., van Laar PJ; Department of Radiology, Hospital Group Twente, Almelo and Hengelo, The Netherlands., Enting RH; Department of Neurology, University Medical Center Groningen, Groningen, The Netherlands., Dierckx RAJO; Department of Nuclear Medicine, Medical Imaging Center (MIC), University Medical Center Groningen, Groningen, The Netherlands., Stormezand GN; Department of Nuclear Medicine, Medical Imaging Center (MIC), University Medical Center Groningen, Groningen, The Netherlands., van der Hoorn A; Department of Radiology, Medical Imaging Center (MIC), University Medical Center Groningen, P.O. Box 30.001, 9700 RB, Groningen, The Netherlands.
Jazyk: angličtina
Zdroj: Neuroradiology [Neuroradiology] 2022 Feb; Vol. 64 (2), pp. 247-252. Date of Electronic Publication: 2021 Jun 10.
DOI: 10.1007/s00234-021-02742-7
Abstrakt: Purpose: Ventricle contact is associated with a worse prognosis and more aggressive tumor characteristics in glioblastoma (GBM). This is hypothesized to be a result of neural stem cells located around the lateral ventricles, in the subventricular zone. 11C Methionine positron emission tomography (metPET) is an indicator for increased proliferation, as it shows uptake of methionine, an amino acid needed for protein synthesis. This study is the first to study metPET characteristics of GBM in relation to ventricle contact.
Methods: A total of 12 patients with IDH wild-type GBM were included. Using MRI, the following regions were determined: primary tumor (defined as contrast enhancing lesion on T1) and peritumoral edema (defined as edema visible on FLAIR excluding the enhancement). PET parameters in these areas were extracted using PET fused with MRI imaging. Parameters extracted from the PET included maximum and mean tumor-to-normal ratio (TNRmax and TNRmean) and metabolic tumor volume (MTV).
Results: TNRmean of the primary tumor showed significantly higher values for the ventricle-contacting group compared to that for the non-contacting group (4.44 vs 2.67, p = 0.030). Other metPET parameters suggested higher values for the ventricle-contacting group, but these differences did not reach statistical significance.
Conclusion: GBM with ventricle contact demonstrated a higher methionine uptake and might thus have increased proliferation compared with GBM without ventricle contact. This might explain survival differences and should be considered in treatment decisions.
(© 2021. The Author(s).)
Databáze: MEDLINE
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