| Autor: |
de Kock CPJ; Department of Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research, Neuroscience Campus Amsterdam, VU, Amsterdam, the Netherlands. ckock@falw.vu.nl., Pie J; Department of Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research, Neuroscience Campus Amsterdam, VU, Amsterdam, the Netherlands.; University of Amsterdam, Swammerdam Institute for Life Sciences, Amsterdam, Netherlands., Pieneman AW; Department of Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research, Neuroscience Campus Amsterdam, VU, Amsterdam, the Netherlands., Mease RA; Institute of Physiology and Pathophysiology, Heidelberg University, Heidelberg, Germany., Bast A; Max Planck Group: In Silico Brain Sciences, Center of Advanced European Studies and Research, Bonn, Germany., Guest JM; Max Planck Group: In Silico Brain Sciences, Center of Advanced European Studies and Research, Bonn, Germany., Oberlaender M; Max Planck Group: In Silico Brain Sciences, Center of Advanced European Studies and Research, Bonn, Germany., Mansvelder HD; Department of Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research, Neuroscience Campus Amsterdam, VU, Amsterdam, the Netherlands., Sakmann B; Max Planck Institute for Neurobiology, Martinsried, Germany. |
| Abstrakt: |
Diversity of cell-types that collectively shape the cortical microcircuit ensures the necessary computational richness to orchestrate a wide variety of behaviors. The information content embedded in spiking activity of identified cell-types remain unclear to a large extent. Here, we recorded spike responses upon whisker touch of anatomically identified excitatory cell-types in primary somatosensory cortex in naive, untrained rats. We find major differences across layers and cell-types. The temporal structure of spontaneous spiking contains high-frequency bursts (≥100 Hz) in all morphological cell-types but a significant increase upon whisker touch is restricted to layer L5 thick-tufted pyramids (L5tts) and thus provides a distinct neurophysiological signature. We find that whisker touch can also be decoded from L5tt bursting, but not from other cell-types. We observed high-frequency bursts in L5tts projecting to different subcortical regions, including thalamus, midbrain and brainstem. We conclude that bursts in L5tts allow accurate coding and decoding of exploratory whisker touch. |
