A probiotic has differential effects on allergic airway inflammation in A/J and C57BL/6 mice and is correlated with the gut microbiome.

Autor: Casaro MB; Department of Pharmaceutics Sciences, Institute of Environmental, Chemistry and Pharmaceutical Sciences, Universidade Federal de São Paulo, R. São Nicolau, 210, Diadema, SP, 09913-03, Brazil., Thomas AM; Department CIBIO, University of Trento, Trento, Italy.; Medical Genomics Laboratory, CIPE/A.C. Camargo Cancer Center, São Paulo, Brazil.; Department of Biochemistry, Institute of Chemistry, Universidade de São Paulo, São Paulo, Brazil., Mendes E; Department of Pharmaceutics Sciences, Institute of Environmental, Chemistry and Pharmaceutical Sciences, Universidade Federal de São Paulo, R. São Nicolau, 210, Diadema, SP, 09913-03, Brazil., Fukumori C; Department of Pharmaceutics Sciences, Institute of Environmental, Chemistry and Pharmaceutical Sciences, Universidade Federal de São Paulo, R. São Nicolau, 210, Diadema, SP, 09913-03, Brazil., Ribeiro WR; Department of Pharmaceutics Sciences, Institute of Environmental, Chemistry and Pharmaceutical Sciences, Universidade Federal de São Paulo, R. São Nicolau, 210, Diadema, SP, 09913-03, Brazil., Oliveira FA; Center for Mathematics, Computing and Cognition (CMCC), Federal University of ABC - UFABC, São Bernardo do Campo, SP, Brazil., Crisma AR; Department of Clinical Analyses, Universidade Federal do Paraná, Curitiba, Brazil., Murata GM; Department of Medical Clinic, Faculty of Medicine, University of São Paulo, São Paulo, 01246-903, Brazil., Bizzarro B; Department of Immunology, Institute of Biomedical Sciences, Universidade de São Paulo, São Paulo, Brazil., Sá-Nunes A; Department of Immunology, Institute of Biomedical Sciences, Universidade de São Paulo, São Paulo, Brazil., Setubal JC; Department of Biochemistry, Institute of Chemistry, Universidade de São Paulo, São Paulo, Brazil., Mayer MPA; Department of Microbiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, SP, Brazil., Martins FS; Department of Microbiology, Institute of Biological Sciences, Federal Universidade de Minas Gerais, Belo Horizonte, Brazil., Vieira AT; Department of Biochemistry and Immunology, Biological Science Institute, Federal University of Minas Gerais, Belo Horizonte, Brazil., Antiorio ATFB; Department of Pathology, School of Veterinary Medicine and Animal Science, Universidade de São Paulo, São Paulo, Brazil., Tavares-de-Lima W; Department of Pharmacology, Institute of Biomedical Sciences I, Universidade de São Paulo, São Paulo, Brazil., Camara NOS; Department of Immunology, Institute of Biomedical Sciences, Universidade de São Paulo, São Paulo, Brazil., Curi R; Interdisciplinary Post-Graduate Program in Health Sciences, Cruzeiro do Sul University, São Paulo, Brazil., Dias-Neto E; Medical Genomics Laboratory, CIPE/A.C. Camargo Cancer Center, São Paulo, Brazil.; Laboratory of Neurosciences (LIM-27), Institute of Psychiatry, Medical School, Universidade de São Paulo, São Paulo, Brazil., Ferreira CM; Department of Pharmaceutics Sciences, Institute of Environmental, Chemistry and Pharmaceutical Sciences, Universidade Federal de São Paulo, R. São Nicolau, 210, Diadema, SP, 09913-03, Brazil. cferreira16@unifesp.br.
Jazyk: angličtina
Zdroj: Microbiome [Microbiome] 2021 Jun 10; Vol. 9 (1), pp. 134. Date of Electronic Publication: 2021 Jun 10.
DOI: 10.1186/s40168-021-01081-2
Abstrakt: The phenotypes of allergic airway diseases are influenced by the interplay between host genetics and the gut microbiota, which may be modulated by probiotics. We investigated the probiotic effects on allergic inflammation in A/J and C57BL/6 mice. C57BL/6 mice had increased gut microbiota diversity compared to A/J mice at baseline. Acetate producer probiotics differentially modulated and altered the genus abundance of specific bacteria, such as Akkermansia and Allistipes, in mouse strains. We induced airway inflammation followed by probiotic treatment and found that only A/J mice exhibited decreased inflammation, and the beneficial effects of probiotics in A/J mice were partially due to acetate production. To understand the relevance of microbial composition colonization in the development of allergic diseases, we implanted female C57BL/6 mice with A/J embryos to naturally modulate the microbial composition of A/J mice, which increased gut microbiota diversity and reduced eosinophilic inflammation in A/J. These data demonstrate the central importance of microbiota to allergic phenotype severity. Video Abstract.
Databáze: MEDLINE
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