Clinical utility of the imunohistochemical co-expression of p53 and MDM2 in thyroid follicular lesions.

Autor: Martins MB; Laboratory of Cancer Molecular Genetics, Faculty of Medical Sciences (FCM), University of Campinas (UNICAMP), Campinas, SP, Brazil., de Assis Batista F; Laboratory of Cancer Molecular Genetics, Faculty of Medical Sciences (FCM), University of Campinas (UNICAMP), Campinas, SP, Brazil., Marcello MA; Laboratory of Cancer Molecular Genetics, Faculty of Medical Sciences (FCM), University of Campinas (UNICAMP), Campinas, SP, Brazil., Bufalo NE; Laboratory of Cancer Molecular Genetics, Faculty of Medical Sciences (FCM), University of Campinas (UNICAMP), Campinas, SP, Brazil., Peres KC; Laboratory of Cancer Molecular Genetics, Faculty of Medical Sciences (FCM), University of Campinas (UNICAMP), Campinas, SP, Brazil. Electronic address: karinacolombera@gmail.com., Morari EC; Laboratory of Cancer Molecular Genetics, Faculty of Medical Sciences (FCM), University of Campinas (UNICAMP), Campinas, SP, Brazil; Department of Biological and Health Sciences, State University of Roraima, Boa Vista, Brazil., Soares FA; Department of General Pathology, Dental School, University of São Paulo, São Paulo, Brazil; Pathology Division, ID'Or Research Institute, Rede D'Or Hospitals Network, São Paulo, Brazil., Vassallo J; Laboratory Investigative and Molecular Pathology, CIPED, Faculty of Medical Sciences (FCM), University of Campinas (UNICAMP), Campinas, SP, Brazil., Ward LS; Laboratory of Cancer Molecular Genetics, Faculty of Medical Sciences (FCM), University of Campinas (UNICAMP), Campinas, SP, Brazil.
Jazyk: angličtina
Zdroj: Annals of diagnostic pathology [Ann Diagn Pathol] 2021 Aug; Vol. 53, pp. 151766. Date of Electronic Publication: 2021 May 31.
DOI: 10.1016/j.anndiagpath.2021.151766
Abstrakt: In order to investigate the possible correlation between p53 and MDM2 co-expression with clinicopathological features of differentiated thyroid cancer (DTC) and its use as diagnostic and/or prognostic markers, we used immunohistochemistry to evaluate 317 thyroid samples including 208 DTC and 94 benign nodules, in addition to 15 normal tissues. MDM2 and p53 expression were highly associated (r = 0.7161; p < 0.0001). The co-expression of p53-MDM2 was observed more frequently in malignant lesions (p < 0.0001) and helped characterize follicular patterned lesions distinguishing FVPTC from FA (p < 0.0001) and FVPTC from FTC (p < 0.0001). In addition, p53-MDM2 co-expression was associated with characteristics of less aggressiveness. It was more frequent in patients ≤45 years old (p = 0.0035), with unique tumors (p = 0.0095), tumors <2 cm (p < 0.0001), tumors without extrathyroid invasion (p = 0.0425), without metastasis at evolution (p = 0.0179), and in patients evolving free of disease after treatment (p = 0.0485). We suggest that p53-MDM2 co-expression profile analysis might help establishing diagnostic and determining prognostic of DTC patients.
(Copyright © 2021 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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