Polyprenylated acylphloroglucinol meroterpenoids with PTP1B inhibition from Hypericum forrestii.

Autor: Zong JF; School of Pharmacy, Fudan University, Shanghai 201203, China., Zhang MM; National Center for Drug Screening, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China., Zhou YB; National Center for Drug Screening, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China., Li J; National Center for Drug Screening, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China., Hou AJ; School of Pharmacy, Fudan University, Shanghai 201203, China. Electronic address: ajhou@shmu.edu.cn., Lei C; School of Pharmacy, Fudan University, Shanghai 201203, China. Electronic address: chunlei@fudan.edu.cn.
Jazyk: angličtina
Zdroj: Fitoterapia [Fitoterapia] 2021 Sep; Vol. 153, pp. 104959. Date of Electronic Publication: 2021 Jun 07.
DOI: 10.1016/j.fitote.2021.104959
Abstrakt: Three new polyprenylated acylphloroglucinol meroterpenoids, hyperiforins A-C (1-3), were isolated from Hypericum forrestii (Chittenden) N. Robson, together with twelve known analogues (4-15). Their structures were established by extensive physical and spectroscopic data analysis. Compounds 1, 2, 5, 7, and 13-15 showed potent inhibitory effects on protein tyrosine phosphatase 1B with IC 50 values from 6.63 ± 2.40 to 14.21 ± 3.51 μM.
(Copyright © 2021 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: