Dispersal strategies shape persistence and evolution of human gut bacteria.

Autor:	Hildebrand F; Gut Microbes and Health, Quadram Institute Bioscience, NR4 7UQ Norwich, UK; Digital Biology, Earlham Institute, NR4 7UZ Norwich, UK; European Molecular Biology Laboratory, Structural and Computational Biology Unit, 69117 Heidelberg, Germany. Electronic address: falk.hildebrand@quadram.ac.uk., Gossmann TI; Department of Animal Behaviour, Bielefeld University, Bielefeld DE-33501, Germany., Frioux C; Gut Microbes and Health, Quadram Institute Bioscience, NR4 7UQ Norwich, UK; Inria, INRAE, CNRS, Univ. Bordeaux, 33405 Talence, France., Özkurt E; Gut Microbes and Health, Quadram Institute Bioscience, NR4 7UQ Norwich, UK; Digital Biology, Earlham Institute, NR4 7UZ Norwich, UK., Myers PN; Clinical Microbiomics A/S, Copenhagen, Denmark; Department of Biotechnology and Biomedicine, Technical University of Denmark, DK-2800 Kgs. Lyngby, Denmark., Ferretti P; European Molecular Biology Laboratory, Structural and Computational Biology Unit, 69117 Heidelberg, Germany., Kuhn M; European Molecular Biology Laboratory, Structural and Computational Biology Unit, 69117 Heidelberg, Germany., Bahram M; Department of Ecology, Swedish University of Agricultural Sciences, Ulls väg 16, 750 07 Uppsala, Sweden; Institute of Ecology and Earth Sciences, University of Tartu, Vanemuise 46, 51014 Tartu, Estonia., Nielsen HB; Clinical Microbiomics A/S, Copenhagen, Denmark., Bork P; European Molecular Biology Laboratory, Structural and Computational Biology Unit, 69117 Heidelberg, Germany; Max Delbrück Center for Molecular Medicine, Berlin, Germany; Yonsei Frontier Lab (YFL), Yonsei University, Seoul 03722, South Korea; Department of Bioinformatics, Biocenter, University of Würzburg, Würzburg, Germany. Electronic address: bork@embl.de.
Jazyk:	angličtina
Zdroj:	Cell host & microbe [Cell Host Microbe] 2021 Jul 14; Vol. 29 (7), pp. 1167-1176.e9. Date of Electronic Publication: 2021 Jun 09.
DOI:	10.1016/j.chom.2021.05.008
Abstrakt:	Human gut bacterial strains can co-exist with their hosts for decades, but little is known about how these microbes persist and disperse, and evolve thereby. Here, we examined these processes in 5,278 adult and infant fecal metagenomes, longitudinally sampled in individuals and families. Our analyses revealed that a subset of gut species is extremely persistent in individuals, families, and geographic regions, represented often by locally successful strains of the phylum Bacteroidota. These "tenacious" bacteria show high levels of genetic adaptation to the human host but a high probability of loss upon antibiotic interventions. By contrast, heredipersistent bacteria, notably Firmicutes, often rely on dispersal strategies with weak phylogeographic patterns but strong family transmissions, likely related to sporulation. These analyses describe how different dispersal strategies can lead to the long-term persistence of human gut microbes with implications for gut flora modulations. Competing Interests: Declaration of interests The authors declare no competing interests (Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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