Continuous glucose monitoring in obese pregnant women with no hyperglycemia on glucose tolerance test.

Autor: Rahmi RM; Department of Endocrinology, General Hospital of Caxias do Sul, Caxias do Sul University, Caxias do Sul, RS, Brazil., de Oliveira P; Master Degree Student in Health Sciences, Caxias do Sul University, Caxias do Sul, RS, Brazil., Selistre L; Department of Nephrology, General Hospital of Caxias do Sul, Caxias do Sul, RS, Brazil., Rezende PC; Department of Atherosclerosis, Heart Institute of the University of São Paulo Medical School, São Paulo, SP, Brazil., Pezzella GN; Institutional Scientific Initiation Scholarship Program of Caxias do Sul University, Caxias do Sul, RS, Brazil., Dos Santos PA; Department of Nutrition, Caxias do Sul University, Caxias do Sul, RS, Brazil., Vergani DOP; Department of Nursing, Caxias do Sul University, Caxias do Sul, RS, Brazil., Madi SRC; Department of Obstetrics and Gynecology, General Hospital of Caxias do Sul, Caxias do Sul University, Caxias do Sul, RS, Brazil., Madi JM; Department of Obstetrics and Gynecology, General Hospital of Caxias do Sul, Caxias do Sul University, Caxias do Sul, RS, Brazil.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2021 Jun 10; Vol. 16 (6), pp. e0253047. Date of Electronic Publication: 2021 Jun 10 (Print Publication: 2021).
DOI: 10.1371/journal.pone.0253047
Abstrakt: Objective: The objective of the present study was to compare 24-hour glycemic levels between obese pregnant women with normal glucose tolerance and non-obese pregnant women.
Methods: In the present observational, longitudinal study, continuous glucose monitoring was performed in obese pregnant women with normal oral glucose tolerance test with 75 g of glucose between the 24th and the 28th gestational weeks. The control group (CG) consisted of pregnant women with normal weight who were selected by matching the maternal age and parity with the same characteristics of the obese group (OG). Glucose measurements were obtained during 72 hours.
Results: Both the groups were balanced in terms of baseline characteristics (age: 33.5 [28.7-36.0] vs. 32.0 [26.0-34.5] years, p = 0.5 and length of pregnancy: 25.0 [24.0-25.0] vs. 25.5 [24.0-28.0] weeks, p = 0.6 in the CG and in the OG, respectively). Pre-breakfast glycemic levels were 77.77 ± 10.55 mg/dL in the CG and 82.02 ± 11.06 mg/dL in the OG (p<0.01). Glycemic levels at 2 hours after breakfast were 87.31 ± 13.10 mg/dL in the CG and 93.48 ± 18.74 mg/dL in the OG (p<0.001). Daytime blood glucose levels were 87.6 ± 15.4 vs. 93.1 ± 18.3 mg/dL (p<0.001) and nighttime blood glucose levels were 79.3 ± 15.8 vs. 84.7 ± 16.3 mg/dL (p<0.001) in the CG and in the OG, respectively. The 24-hour, daytime, and nighttime values of the area under the curve were higher in the OG when compared with the CG (85.1 ± 0.16 vs. 87.9 ± 0.12, 65.6 ± 0.14 vs. 67.5 ± 0.10, 19.5 ± 0.07 vs. 20.4 ± 0.05, respectively; p<0.001).
Conclusion: The results of the present study showed that obesity in pregnancy was associated with higher glycemic levels even in the presence of normal findings on glucose tolerance test.
Competing Interests: The authors have declared that no competing interests exist.
Databáze: MEDLINE
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