Galectin-3 immunolabelling correlates with BCL2 expression in canine cutaneous mast cell tumours.

Autor:	Vargas THM; 1Laboratório de Oncologia Comparada e Translacional (LOCT), Departamento de Medicina Veterinária, Faculdade de Zootecnia e Engenharia de Alimentos, Universidade de São Paulo, Av. Duque de Caxias Norte 225, Jd. Elite, Pirassununga, CEP 13635-900, São Paulo, Brazil., Barra CN; 1Laboratório de Oncologia Comparada e Translacional (LOCT), Departamento de Medicina Veterinária, Faculdade de Zootecnia e Engenharia de Alimentos, Universidade de São Paulo, Av. Duque de Caxias Norte 225, Jd. Elite, Pirassununga, CEP 13635-900, São Paulo, Brazil.; 2Departamento de Patologia, Faculdade de Medicina Veterinária e Zootecnia, Universidade de São Paulo, São Paulo, SP, Brazil., Pulz LH; 1Laboratório de Oncologia Comparada e Translacional (LOCT), Departamento de Medicina Veterinária, Faculdade de Zootecnia e Engenharia de Alimentos, Universidade de São Paulo, Av. Duque de Caxias Norte 225, Jd. Elite, Pirassununga, CEP 13635-900, São Paulo, Brazil.; 2Departamento de Patologia, Faculdade de Medicina Veterinária e Zootecnia, Universidade de São Paulo, São Paulo, SP, Brazil., Huete GC; 1Laboratório de Oncologia Comparada e Translacional (LOCT), Departamento de Medicina Veterinária, Faculdade de Zootecnia e Engenharia de Alimentos, Universidade de São Paulo, Av. Duque de Caxias Norte 225, Jd. Elite, Pirassununga, CEP 13635-900, São Paulo, Brazil., Cadrobbi KG; 1Laboratório de Oncologia Comparada e Translacional (LOCT), Departamento de Medicina Veterinária, Faculdade de Zootecnia e Engenharia de Alimentos, Universidade de São Paulo, Av. Duque de Caxias Norte 225, Jd. Elite, Pirassununga, CEP 13635-900, São Paulo, Brazil., Nishiya AT; 3Universidade Anhembi Morumbi, São Paulo, SP, Brazil., Kleeb SR; 3Universidade Anhembi Morumbi, São Paulo, SP, Brazil., Xavier JG; 4Universidade Paulista, São Paulo, SP, Brazil., Catão-Dias JL; 2Departamento de Patologia, Faculdade de Medicina Veterinária e Zootecnia, Universidade de São Paulo, São Paulo, SP, Brazil., Strefezzi RF; 1Laboratório de Oncologia Comparada e Translacional (LOCT), Departamento de Medicina Veterinária, Faculdade de Zootecnia e Engenharia de Alimentos, Universidade de São Paulo, Av. Duque de Caxias Norte 225, Jd. Elite, Pirassununga, CEP 13635-900, São Paulo, Brazil.
Jazyk:	angličtina
Zdroj:	Acta veterinaria Hungarica [Acta Vet Hung] 2021 Jun 09; Vol. 69 (2), pp. 169-174. Date of Electronic Publication: 2021 Jun 09.
DOI:	10.1556/004.2021.00019
Abstrakt:	Mast cell tumour (MCT) is the most frequent skin neoplasm in dogs. These tumours are characterised by variable behaviour and clinical presentation that make prognosis an important and challenging task in the veterinary practice. Galectin-3 (Gal-3) is known to influence several biological processes that are important in the cancer context and has been described as a prognostic marker for several human cancers. The aim of the present work was to characterise Gal-3 immunolabelling in canine cutaneous MCTs and to investigate its value as a prognostic marker for the disease. Thirty-four random cases of canine cutaneous MCT that were surgically treated with wide margins were included in this study. Gal-3 expression was evaluated using immunohistochemistry and the results were compared with the expression of apoptosis-related proteins, Ki67 index, histopathological grades, mortality due to the disease and post-surgical survival. The majority of the MCTs (65.8%) were positive for Gal-3. Gal-3 immunolabelling was variable among the samples (2.7%-86.8% of the neoplastic cells). The protein was located in the cytoplasm or in the cytoplasm and the nucleus. Gal-3 positivity was correlated with BCL2 expression (P < 0.001; r = 0.604), but not with Ki67 and BAX. No significant differences were detected between histological grades or in the survival analysis. Gal-3 expression correlates with BCL2 expression in MCTs. Although an efficient marker for several human neoplasms, the results presented herein suggest that Gal-3 immunolabelling is not an independent prognostic indicator for this disease.
Databáze:	MEDLINE
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