PharmVar GeneFocus: CYP2C9.

Autor: Sangkuhl K; Department of Biomedical Data Science, School of Medicine, Stanford University, Stanford, California, USA., Claudio-Campos K; Department of Pharmacotherapy and Translational Research, College of Pharmacy, University of Florida, Gainesville, Florida, USA., Cavallari LH; Department of Pharmacotherapy and Translational Research, Center for Pharmacogenomics and Precision Medicine, University of Florida, Gainesville, Florida, USA., Agundez JAG; University Institute of Molecular Pathology Biomarkers, University of Extremadura, Asthma, Adverse Drug Reactions and Allergy (ARADyAL) Institute de Salud Carlos III, Cáceres, Spain., Whirl-Carrillo M; Department of Biomedical Data Science, School of Medicine, Stanford University, Stanford, California, USA., Duconge J; School of Pharmacy, University of Puerto Rico Medical Sciences Campus, San Juan, Puerto Rico, USA., Del Tredici AL; Acadia Pharmaceuticals Inc., San Diego, California, USA., Wadelius M; Department of Medical Sciences, Clinical Pharmacology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden., Rodrigues Botton M; Cells, Tissues and Genes Laboratory, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil., Woodahl EL; Department of Biomedical and Pharmaceutical Sciences, University of Montana, Missoula, Montana, USA., Scott SA; Department of Pathology, Stanford University, Stanford, California, USA.; Stanford Health Care Clinical Genomics Laboratory, Palo Alto, California, USA., Klein TE; Department of Biomedical Data Science, School of Medicine, Stanford University, Stanford, California, USA., Pratt VM; Indiana University School of Medicine, Indianapolis, Indiana, USA., Daly AK; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK., Gaedigk A; Division of Clinical Pharmacology, Toxicology & Therapeutic Innovation, Children's Mercy Kansas City, Kansas City, Missouri, USA.; School of Medicine, University of Missouri - Kansas City, Kansas City, Missouri, USA.
Jazyk: angličtina
Zdroj: Clinical pharmacology and therapeutics [Clin Pharmacol Ther] 2021 Sep; Vol. 110 (3), pp. 662-676. Date of Electronic Publication: 2021 Jul 12.
DOI: 10.1002/cpt.2333
Abstrakt: The Pharmacogene Variation Consortium (PharmVar) catalogues star (*) allele nomenclature for the polymorphic human CYP2C9 gene. Genetic variation within the CYP2C9 gene locus impacts the metabolism or bioactivation of many clinically important drugs, including nonsteroidal anti-inflammatory drugs, phenytoin, antidiabetic agents, and angiotensin receptor blockers. Variable CYP2C9 activity is of particular importance regarding efficacy and safety of warfarin and siponimod as indicated in their package inserts. This GeneFocus provides a comprehensive overview and summary of CYP2C9 and describes how haplotype information catalogued by PharmVar is utilized by the Pharmacogenomics Knowledgebase and the Clinical Pharmacogenetics Implementation Consortium.
(© 2021 The Authors. Clinical Pharmacology & Therapeutics © 2021 American Society for Clinical Pharmacology and Therapeutics.)
Databáze: MEDLINE
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