Tissue mechanics in stem cell fate, development, and cancer.

Autor:	Hayward MK; Center for Bioengineering and Tissue Regeneration, Department of Surgery, University of California, San Francisco, San Francisco, CA 94143, USA., Muncie JM; Gladstone Institutes, San Francisco, CA 94158, USA., Weaver VM; Center for Bioengineering and Tissue Regeneration, Department of Surgery, University of California, San Francisco, San Francisco, CA 94143, USA; Department of Bioengineering and Therapeutic Sciences and Department of Radiation Oncology, Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA 94143, USA; The Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address: valerie.weaver@ucsf.edu.
Jazyk:	angličtina
Zdroj:	Developmental cell [Dev Cell] 2021 Jul 12; Vol. 56 (13), pp. 1833-1847. Date of Electronic Publication: 2021 Jun 08.
DOI:	10.1016/j.devcel.2021.05.011
Abstrakt:	Cells in tissues experience a plethora of forces that regulate their fate and modulate development and homeostasis. Cells sense mechanical cues through localized mechanoreceptors or by influencing cytoskeletal or plasma membrane organization. Cells translate force and modulate their behavior through a process termed mechanotransduction. Cells tune their tension upon exposure to chronic force by engaging cellular machinery that modulates actin tension, which in turn stimulates matrix remodeling and stiffening and alters cell-cell adhesions until cells achieve a state of tensional homeostasis. Loss of tensional homeostasis can be induced through oncogene activity and/or tissue fibrosis, accompanies tumor progression, and is associated with increased cancer risk. The mechanical stresses that develop in tumors can also foster the mesenchymal-like transdifferentiation of cells to induce a stem-like phenotype that contributes to their aggression, metastatic dissemination, and treatment resistance. Thus, strategies that ameliorate tumor mechanics may comprise an effective strategy to prevent aggressive tumor behavior. Competing Interests: Declaration of interests V.M. Weaver is a member of the advisory board for Developmental Cell, but she did not participate in the editorial process of this manuscript. (Copyright © 2021 Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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