Leiomyoma and Leiomyosarcoma (Primary and Metastatic) of the Oral and Maxillofacial Region: A Clinicopathological and Immunohistochemical Study of 27 Cases.

Autor: de Araújo GR; Department of Oral Surgery and Pathology, School of Dentistry, Federal University of Minas Gerais, Belo Horizonte, Brazil., Costa SFDS; Department of Oral Surgery and Pathology, School of Dentistry, Federal University of Minas Gerais, Belo Horizonte, Brazil., Mesquita RA; Department of Oral Surgery and Pathology, School of Dentistry, Federal University of Minas Gerais, Belo Horizonte, Brazil., Gomez RS; Department of Oral Surgery and Pathology, School of Dentistry, Federal University of Minas Gerais, Belo Horizonte, Brazil., Dos Santos JN; Department of Oral Surgery and Pathology, School of Dentistry, Federal University of Bahia, Salvador, Brazil., Pontes HAR; Service of Oral Pathology, João de Barros Barreto University Hospital, Federal University of Pará, Belém, Brazil., de Andrade BAB; Department of Oral Diagnosis and Pathology, School of Dentistry, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil., Romañach MJ; Department of Oral Diagnosis and Pathology, School of Dentistry, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil., Agostini M; Department of Oral Diagnosis and Pathology, School of Dentistry, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil., Vargas PA; Oral Diagnosis Department (Pathology and Semiology Areas), Piracicaba Dental School, University of Campinas, Piracicaba, Brazil.; Department of Oral Biology and Oral Pathology, School of Dentistry, University of Pretoria, Pretoria, South Africa., de Cáceres CVBL; Oral Diagnosis Department (Pathology and Semiology Areas), Piracicaba Dental School, University of Campinas, Piracicaba, Brazil., Santos-Silva AR; Oral Diagnosis Department (Pathology and Semiology Areas), Piracicaba Dental School, University of Campinas, Piracicaba, Brazil., Ribeiro ACP; Dental Oncology Service, Instituto do Câncer do Estado de São Paulo, São Paulo, Brazil., Brandão TB; Dental Oncology Service, Instituto do Câncer do Estado de São Paulo, São Paulo, Brazil., Tomasi RA; Deparment of Pathology, Dental School, National University of Córdoba, Córdoba, Argentina., Ferreyra RS; Deparment of Pathology, Dental School, National University of Córdoba, Córdoba, Argentina., de Almeida OP; Oral Diagnosis Department (Pathology and Semiology Areas), Piracicaba Dental School, University of Campinas, Piracicaba, Brazil., Fonseca FP; Department of Oral Surgery and Pathology, School of Dentistry, Federal University of Minas Gerais, Belo Horizonte, Brazil. felipepfonseca@hotmail.com.; Department of Oral Biology and Oral Pathology, School of Dentistry, University of Pretoria, Pretoria, South Africa. felipepfonseca@hotmail.com.
Jazyk: angličtina
Zdroj: Head and neck pathology [Head Neck Pathol] 2022 Mar; Vol. 16 (1), pp. 294-303. Date of Electronic Publication: 2021 Jun 09.
DOI: 10.1007/s12105-021-01336-2
Abstrakt: Smooth muscle neoplasms represent an important group of lesions which is rare in the oral cavity. Leiomyoma (LM) is benign smooth muscle/pericytic tumor usually presenting as non-aggressive neoplasm, while leiomyosarcoma (LMS) represents its malignant counterpart. The rarity of these lesions, together with its unspecific clinical presentation and a variable histopathological appearance, lead to a broad list of differential diagnoses, hampering their diagnoses. Therefore, in this study we describe the clinical and microscopic features of a series of oral and maxillofacial LMs and LMSs. A retrospective search from 2000 to 2019 was performed and all cases diagnosed as LM and LMS affecting the oral cavity and gnathic bones were retrieved. Clinical and demographic data were obtained from the patients' pathology records, while microscopic features and immunohistochemistry were reviewed and completed when necessary to confirm the diagnoses. Twenty-two LMs and five LMSs were obtained. In the LM group, males predominated, with a mean age of 45.7 years. The upper lip was the most affected site, and 18 cases were classified as angioleiomyomas and four as solid LM. In the LMS group, females predominated, with a mean age of 47.6 years. The mandible was the most affected site. Diffuse proliferation of spindle cells, with necrosis and mitotic figures, were frequent microscopic findings. LMs and LMSs were positive for α-smooth muscle actin, HHF-35 and h-caldesmon. In conclusion, oral LM/LMS are uncommon neoplasms with the latter usually presenting as metastatic disease. H&E evaluation may be very suggestive of oral LMs, but h-caldesmon staining is strongly recommended to confirm LMS diagnosis.
(© 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
Externí odkaz: