[Corneal wound healing-Pathophysiology and principles].

Autor: Brockmann T; Klinik und Poliklinik für Augenheilkunde, Universitätsmedizin Rostock, Doberaner Straße 140, 18057, Rostock, Deutschland. tobias.brockmann@med.uni-rostock.de., Walckling M; Klinik und Poliklinik für Augenheilkunde, Universitätsmedizin Rostock, Doberaner Straße 140, 18057, Rostock, Deutschland., Brockmann C; Klinik und Poliklinik für Augenheilkunde, Universitätsmedizin Rostock, Doberaner Straße 140, 18057, Rostock, Deutschland., Fuchsluger TMA; Klinik und Poliklinik für Augenheilkunde, Universitätsmedizin Rostock, Doberaner Straße 140, 18057, Rostock, Deutschland., Pleyer U; Klinik und Poliklinik für Augenheilkunde, Charité - Universitätsmedizin Berlin, Berlin Institute of Health, Freie Universität Berlin, Humboldt-Universität zu Berlin, Augustenburger Platz 1, Berlin, 13353, Deutschland.
Jazyk: němčina
Zdroj: Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft [Ophthalmologe] 2021 Nov; Vol. 118 (11), pp. 1167-1177. Date of Electronic Publication: 2021 Jun 09.
DOI: 10.1007/s00347-021-01423-3
Abstrakt: The cornea forms the anterior border of the eye and significantly contributes to a sharp optical image quality on the retina through its transparency, avascular nature and curvature. Because of its anatomical structure and as a barrier to the environment, the cornea is particularly exposed to various external factors, such as injuries and pathogens. A correct wound healing without the formation of light diverging scarring is therefore essential to preserve the integrity and function of the cornea. Misguided wound healing is of outstanding clinical relevance and can lead to corneal fibrogenesis. Corneal fibrosis results in scarring with a loss of optical transparency, which significantly reduces eyesight and can lead to blindness. Understanding the pathophysiological mechanisms of wound healing and fibrogenesis is of great importance for the diagnostics, treatment and evaluation of the subsequent healing process in order to prevent permanent damage as far as possible.
(© 2021. Springer Medizin Verlag GmbH, ein Teil von Springer Nature.)
Databáze: MEDLINE
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