| Autor: |
van der Vet AP; Department of Pulmonology, University Hospital Maastricht, The Netherlands., Quaedvlieg M, Greve LH |
| Jazyk: |
angličtina |
| Zdroj: |
International journal of clinical pharmacology, therapy, and toxicology [Int J Clin Pharmacol Ther Toxicol] 1988 May; Vol. 26 (5), pp. 258-64. |
| Abstrakt: |
In a group of 18 patients with a so-called "morning dip", one single dose of theophylline was administered at 10:00 p.m. by means of a sustained release formulation (Theodur Retard). The dosage of theophylline was adjusted according to the complaints of the patients. Plasma theophylline levels were determined at 10:00 a.m. to prevent theophylline intoxications. The results were objectivated by measuring the PEFR twice/day. When the optimal dosage was obtained, a once/day administration of Theodur Retard at 10:00 p.m. provided an improved peak flow in the early morning, less symptoms at night and a better quality of sleep. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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