Growth of prefrontal and limbic brain regions and anxiety disorders in children born very preterm.

Autor:	Gilchrist CP; School of Health and Biomedical Sciences, RMIT University, Bundoora, Australia.; Victorian Infant Brain Studies, Murdoch Children's Research Institute, Melbourne, Australia.; Developmental Imaging, Murdoch Children's Research Institute, Melbourne, Australia., Thompson DK; Victorian Infant Brain Studies, Murdoch Children's Research Institute, Melbourne, Australia.; Developmental Imaging, Murdoch Children's Research Institute, Melbourne, Australia.; Department of Paediatrics, University of Melbourne, Melbourne, Australia.; Florey Institute of Neuroscience and Mental Health, Melbourne, Australia., Alexander B; Victorian Infant Brain Studies, Murdoch Children's Research Institute, Melbourne, Australia.; Developmental Imaging, Murdoch Children's Research Institute, Melbourne, Australia.; Department of Neurosurgery, Royal Children's Hospital, Melbourne, Australia., Kelly CE; Victorian Infant Brain Studies, Murdoch Children's Research Institute, Melbourne, Australia.; Developmental Imaging, Murdoch Children's Research Institute, Melbourne, Australia., Treyvaud K; Victorian Infant Brain Studies, Murdoch Children's Research Institute, Melbourne, Australia.; La Trobe University, Melbourne, Australia.; Royal Women's Hospital, Melbourne, Victoria, Australia., Matthews LG; Monash Biomedical Imaging, Monash University, Melbourne, Australia.; Turner Institute for Brain and Mental Health, School of Psychological Sciences, Monash University, Clayton, Australia.; Brigham and Women's Hospital, Harvard Medical School, Boston, USA., Pascoe L; Victorian Infant Brain Studies, Murdoch Children's Research Institute, Melbourne, Australia.; Turner Institute for Brain and Mental Health, School of Psychological Sciences, Monash University, Clayton, Australia., Zannino D; Clinical Epidemiology and Biostatistics Unit, Murdoch Children's Research Institute, Melbourne, Australia., Yates R; Victorian Infant Brain Studies, Murdoch Children's Research Institute, Melbourne, Australia.; Turner Institute for Brain and Mental Health, School of Psychological Sciences, Monash University, Clayton, Australia., Adamson C; Developmental Imaging, Murdoch Children's Research Institute, Melbourne, Australia., Tolcos M; School of Health and Biomedical Sciences, RMIT University, Bundoora, Australia., Cheong JLY; Victorian Infant Brain Studies, Murdoch Children's Research Institute, Melbourne, Australia.; Royal Women's Hospital, Melbourne, Victoria, Australia.; Department of Obstetrics and Gynaecology, University of Melbourne, Parkville, Australia., Inder TE; Victorian Infant Brain Studies, Murdoch Children's Research Institute, Melbourne, Australia.; Monash Biomedical Imaging, Monash University, Melbourne, Australia., Doyle LW; Victorian Infant Brain Studies, Murdoch Children's Research Institute, Melbourne, Australia.; Department of Paediatrics, University of Melbourne, Melbourne, Australia.; Royal Women's Hospital, Melbourne, Victoria, Australia.; Department of Obstetrics and Gynaecology, University of Melbourne, Parkville, Australia., Cumberland A; School of Health and Biomedical Sciences, RMIT University, Bundoora, Australia., Anderson PJ; Victorian Infant Brain Studies, Murdoch Children's Research Institute, Melbourne, Australia.; Turner Institute for Brain and Mental Health, School of Psychological Sciences, Monash University, Clayton, Australia.
Jazyk:	angličtina
Zdroj:	Psychological medicine [Psychol Med] 2023 Feb; Vol. 53 (3), pp. 759-770. Date of Electronic Publication: 2021 Jun 09.
DOI:	10.1017/S0033291721002105
Abstrakt:	Background: Children born very preterm (VP) display altered growth in corticolimbic structures compared with full-term peers. Given the association between the cortiocolimbic system and anxiety, this study aimed to compare developmental trajectories of corticolimbic regions in VP children with and without anxiety diagnosis at 13 years. Methods: MRI data from 124 VP children were used to calculate whole brain and corticolimbic region volumes at term-equivalent age (TEA), 7 and 13 years. The presence of an anxiety disorder was assessed at 13 years using a structured clinical interview. Results: VP children who met criteria for an anxiety disorder at 13 years ( n = 16) displayed altered trajectories for intracranial volume (ICV, p < 0.0001), total brain volume (TBV, p = 0.029), the right amygdala ( p = 0.0009) and left hippocampus ( p = 0.029) compared with VP children without anxiety ( n = 108), with trends in the right hippocampus ( p = 0.062) and left medial orbitofrontal cortex ( p = 0.079). Altered trajectories predominantly reflected slower growth in early childhood (0-7 years) for ICV ( β = -0.461, p = 0.020), TBV ( β = -0.503, p = 0.021), left ( β = -0.518, p = 0.020) and right hippocampi ( β = -0.469, p = 0.020) and left medial orbitofrontal cortex ( β = -0.761, p = 0.020) and did not persist after adjusting for TBV and social risk. Conclusions: Region- and time-specific alterations in the development of the corticolimbic system in children born VP may help to explain an increase in anxiety disorders observed in this population.
Databáze:	MEDLINE
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