Estimating population-level of alcohol, tobacco and morphine use in a small Russian region using wastewater-based epidemiology.

Autor: Rozhanets VV; Laboratory of Analytical Toxicology, National Research Center on Addictions, Branch of V. Serbsky NMRCPN, Moscow, Russia., Thai PK; Queensland Alliance for Environmental Health Sciences, The University of Queensland, Brisbane, Australia., Silantyev AS; Laboratory of Analytical Toxicology, National Research Center on Addictions, Branch of V. Serbsky NMRCPN, Moscow, Russia., Gandlevskiy NA; Laboratory of Analytical Toxicology, National Research Center on Addictions, Branch of V. Serbsky NMRCPN, Moscow, Russia., Connor JP; Discipline of Psychiatry, The University of Queensland, Brisbane, Australia.; Centre for Youth Substance Abuse Research, The University of Queensland, Brisbane, Australia., Eganov AA; Sechenov University, Moscow, Russia., Jang M; Genome & Company, Seongnam-si, Republic of Korea., Pirogov AV; Department of Chemistry, M.V. Lomonosov Moscow State University, Moscow, Russia., Shpigun OA; Department of Chemistry, M.V. Lomonosov Moscow State University, Moscow, Russia., Priadka A; All-Russian Research Institute of Physical, Technical and Radio Engineering Measurements, Moscow, Russia., Nosyrev AE; Sechenov University, Moscow, Russia.
Jazyk: angličtina
Zdroj: Drug and alcohol review [Drug Alcohol Rev] 2021 Nov; Vol. 40 (7), pp. 1186-1194. Date of Electronic Publication: 2021 Jun 08.
DOI: 10.1111/dar.13334
Abstrakt: Introduction: Alcohol, tobacco and illicit drug use combined are the largest modifiable health risk factors. Wastewater-based epidemiology (WBE) is a complementary approach for monitoring substance use in the population. In this study we applied WBE technique to a community in the Moscow region to estimate population-level consumption of alcohol, tobacco and morphine.
Methods: Wastewater sampling was carried out over 47 days, in 2018 and 2019, including the New Year period. Analysis of the samples for consumption biomarkers (ethyl sulphate, cotinine and morphine) were undertaken using liquid chromatography tandem mass spectrometry (LC-MS/MS). Daily consumption estimates were then compared with sales/production/prescription data and between different days of the week using Mann-Whitney U test.
Results: Alcohol consumption was significantly higher on Sundays and during the New Year and Russian Christmas period compared to weekdays and Saturdays. Tobacco consumption estimates were largely consistent throughout the week. Morphine was detected by WBE during the monitoring period but was inconsistent with prescription record data.
Discussion and Conclusions: This study provides evidence for the feasibility of conducting WBE in Russia. Estimates of alcohol consumption derived from WBE were higher than average alcohol sales data for the country. The estimated consumption of nicotine is generally consistent with the production data, with estimates higher than in most other countries. Our results also suggest potential illegal use of opioids (morphine-based) in the population. Given the considerable health and economic costs of substance use in Russia, more extensive WBE testing is recommended to inform and evaluate public health policies.
(© 2021 Australasian Professional Society on Alcohol and other Drugs.)
Databáze: MEDLINE
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