Extracellular Vesicle Proteome of Breast Cancer Patients with and Without Cognitive Impairment Following Anthracycline-based Chemotherapy: An Exploratory Study.

Autor:	Koh YQ; Department of Pharmacy, Faculty of Science, National University of Singapore, Singapore., Ng DQ; Department of Clinical Pharmacy Practice, University of California, Irvine, CA, USA., Ng CC; Department of Pharmacy, Faculty of Science, National University of Singapore, Singapore., Boey A; Department of Pharmacy, Faculty of Science, National University of Singapore, Singapore., Wei M; School of Biological Sciences, Nanyang Technological University, Singapore., Sze SK; School of Biological Sciences, Nanyang Technological University, Singapore., Ho HK; Department of Pharmacy, Faculty of Science, National University of Singapore, Singapore., Acharya M; Department of Radiation Oncology, University of California, Irvine, CA, USA., Limoli CL; Department of Radiation Oncology, University of California, Irvine, CA, USA., Chan A; Department of Clinical Pharmacy Practice, University of California, Irvine, CA, USA.; Department of Oncology Pharmacy, National Cancer Centre Singapore, Singapore.
Jazyk:	angličtina
Zdroj:	Biomarker insights [Biomark Insights] 2021 May 24; Vol. 16, pp. 11772719211018204. Date of Electronic Publication: 2021 May 24 (Print Publication: 2021).
DOI:	10.1177/11772719211018204
Abstrakt:	Cognitive impairment due to cancer and its therapy is a major concern among cancer patients and survivors. Extracellular vesicle (EVs) composition altered by cancer and chemotherapy may affect neurological processes such as neuroplasticity, potentially impacting the cognitive abilities of cancer patients and survivors. We investigated the EV proteome of breast cancer patients with and without cognitive impairment following anthracycline-based chemotherapy from longitudinally collected plasma. EVs were cup-shaped and positive for Flotillin-1 and TSG-101. We identified 517 differentially expressed EV proteins between the cognitive impaired and non-impaired groups during and post-chemotherapy. The observed decreased expression of p2X purinoceptor, cofilin-1, ADAM 10, and dynamin-1 in the plasma EVs of the cognitive impaired group may suggest alterations in the mechanisms underlying synaptic plasticity. The reduced expression of tight junction proteins among cognitive-impaired patients may imply weakening of the blood-brain barrier. These EV protein signatures may serve as a fingerprint that underscores the mechanisms underlying cognitive impairment in cancer patients and survivors. Competing Interests: Declaration of conflicting interests:The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. (© The Author(s) 2021.)
Databáze:	MEDLINE
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