Blood pressure in adults with cerebral palsy: a systematic review and meta-analysis of individual participant data.

Autor:	Noten S; Department of Rehabilitation Medicine, Erasmus MC University Medical Center Rotterdam.; Rijndam Rehabilitation, Rotterdam, the Netherlands., van den Berg-Emons RJG; Department of Rehabilitation Medicine, Erasmus MC University Medical Center Rotterdam., Thorpe DE; Division of Physical Therapy, University of North Carolina at Chapel Hill, School of Medicine, Chapel Hill, North Carolina., Heyn PC; Department of Physical Medicine and Rehabilitation, University of Colorado Anschutz Medical Campus.; Center for Gait and Motion Analysis, Children's Hospital Colorado, Aurora, Colorado, USA., Marciniak CM; Department of Physical Medicine and Rehabilitation, Northwestern University Feinberg School of Medicine.; Shirley Ryan AbilityLab, Chicago, Illinois, USA., McPhee PG; Department of Pediatrics.; CanChild Centre for Childhood Disability Research.; School of Rehabilitation Science, McMaster University, Hamilton, Ontario, Canada., Lamberts RP; Division of Orthopaedic Surgery, Department of Surgical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg.; Department of Sport Science, Faculty of Medicine and Health Sciences, Stellenbosch University, Stellenbosch., Langerak NG; Neuroscience Institute and Division of Neurosurgery, Department of Surgery, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa., Verschuren O; Center of Excellence for Rehabilitation Medicine, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University and De Hoogstraat Rehabilitation, Utrecht, The Netherlands., Salokivi T; Support and Expert Center for Persons with Intellectual Disability, KTO, Paimio, Finland., Morrison KM; Department of Pediatrics, Centre for Metabolism, Obesity and Diabetes Research, McMaster University, Hamilton, Ontario, Canada., Peterson MD; Department of Physical Medicine and Rehabilitation, University of Michigan, Ann Arbor, Michigan, USA., Limsakul C; Department of Rehabilitation Medicine, Faculty of Medicine, Prince of Songkla University, Songkhla, Thailand., Stam HJ; Department of Rehabilitation Medicine, Erasmus MC University Medical Center Rotterdam., Papageorgiou G; Department of Biostatistics.; Department of Epidemiology., Versmissen J; Departments of Pharmacy and Internal Medicine, Erasmus MC University Medical Center Rotterdam, Rotterdam, the Netherlands., Van Der Slot WMA; Department of Rehabilitation Medicine, Erasmus MC University Medical Center Rotterdam.; Rijndam Rehabilitation, Rotterdam, the Netherlands.
Jazyk:	angličtina
Zdroj:	Journal of hypertension [J Hypertens] 2021 Oct 01; Vol. 39 (10), pp. 1942-1955.
DOI:	10.1097/HJH.0000000000002912
Abstrakt:	Objectives: This systematic review and meta-analysis was designed to determine the overall mean blood pressure and prevalence of hypertension among a representative sample of adults living with cerebral palsy by combining individual participant data. Additional objectives included estimating variations between subgroups and investigating potential risk factors for hypertension. Methods: Potential datasets were identified by literature searches for studies published between January 2000 and November 2017 and by experts in the field. Samples of adults with cerebral palsy (n ≥ 10, age ≥ 18 years) were included if blood pressure data, cerebral palsy-related factors (e.g. cerebral palsy subtype), and sociodemographic variables (e.g. age, sex) were available. Hypertension was defined as at least 140/90 mmHg and/or use of antihypertensive medication. Results: We included data from 11 international cohorts representing 444 adults with cerebral palsy [median (IQR) age of the sample was 29.0 (23.0-38.0); 51% men; 89% spastic type; Gross Motor Function Classification System levels I-V]. Overall mean SBP was 124.9 mmHg [95% confidence interval (CI) 121.7-128.1] and overall mean DBP was 79.9 mmHg (95% CI 77.2-82.5). Overall prevalence of hypertension was 28.7% (95% CI 18.8-39.8%). Subgroup analysis indicated higher blood pressure levels or higher prevalence of hypertension in adults with cerebral palsy above 40 years of age, men, those with spastic cerebral palsy or those who lived in Africa. BMI, resting heart rate and alcohol consumption were risk factors that were associated with blood pressure or hypertension. Conclusion: Our findings underscore the importance of clinical screening for blood pressure in individuals with cerebral palsy beginning in young adulthood. (Copyright © 2021 The Author(s). Published by Wolters Kluwer Health, Inc.)
Databáze:	MEDLINE
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