The use of bolus in postmastectomy radiation therapy for breast cancer: A systematic review.

Autor: Dahn HM; Department of Radiation Oncology, Dalhousie University, Halifax, Canada. Electronic address: hannah.dahn@dal.ca., Boersma LJ; Department of Radiation Oncology (Maastro), GROW School for Oncology, Maastricht University Medical Centre+, Maastricht, the Netherlands. Electronic address: liesbeth.boersma@maastro.nl., de Ruysscher D; Department of Radiation Oncology (Maastro), GROW School for Oncology, Maastricht University Medical Centre+, Maastricht, the Netherlands. Electronic address: dirk.deruysscher@maastro.nl., Meattini I; Department of Experimental and Clinical Biomedical Sciences 'M. Serio', University of Florence, Radiation Oncology Unit - Oncology Department, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy. Electronic address: icro.meattini@unifi.it., Offersen BV; Department of Experimental Clinical Oncology, Aarhus University Hospital, Aarhus, Denmark. Electronic address: birgoffe@rm.dk., Pignol JP; Department of Radiation Oncology, Dalhousie University, Halifax, Canada. Electronic address: jppignol@accuray.com., Aristei C; Radiation Oncology Section Department of Medicine and Surgery, University of Perugia and Perugia General Hospital, Perugia, Italy. Electronic address: cynthia.aristei@unipg.it., Belkacemi Y; Department of Radiation Oncology and Henri Mondor Breast Center, University of Paris-Est (UPEC), Creteil, France; INSERM Unit 955, Team 21. IMRB, Creteil, France. Electronic address: Yazid.belkacemi@aphp.fr., Benjamin D; Department of Physics, Radiation Oncology, Sheba medical Center, Ramat Gan, Israel. Electronic address: dori.benjamin@sheba.health.gov.il., Bese N; Department of Clinical Senology, Research Institute of Senology Acibadem, Istanbul, Turkey. Electronic address: nuranbese@superonline.com., Coles CE; Department of Oncology, University of Cambridge, Cambridge, UK. Electronic address: colesc@doctors.org.uk., Franco P; Department of Translational Medicine, University of Eastern Piedmont, Novara, Italy; Department of Radiation Oncology, University Hospital 'Maggiore della Carità, Novara, Italy. Electronic address: pierfrancesco.franco@gmail.com., Ho A; Harvard Medical School, Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA, USA. Electronic address: alice.ho@mgh.harvard.edu., Hol S; Instituut Verbeeten, Tilburg, the Netherlands. Electronic address: hol.s@bvi.nl., Jagsi R; Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan, USA. Electronic address: rjagsi@med.umich.edu., Kirby AM; Department of Radiotherapy, Royal Marsden NHS Foundation Trust and Institute of Cancer Research, Sutton, UK. Electronic address: anna.kirby@rmh.nhs.uk., Marrazzo L; Medical Physics Unit, Careggi University Hospital, Florence, Italy. Electronic address: livia.marrazzo@unifi.it., Marta GN; Department of Radiation Oncology - Hospital Sírio-Libanês, São Paulo, Brazil. Electronic address: gustavonmarta@gmail.com., Moran MS; Yale School of Medicine, USA. Electronic address: Meena.moran@yale.edu., Nichol AM; Department of Radiation Oncology, BC Cancer - Vancouver, Vancouver, BC, Canada. Electronic address: anichol@bccancer.bc.ca., Nissen HD; Department of Oncology, Vejle Hospital, Denmark. Electronic address: Henrik.dahl.nissen@rsyd.dk., Strnad V; Dept. of Radiation Oncology, University Hospital Erlangen, Erlangen, Germany. Electronic address: vratislav.strnad@uk-erlangen.de., Zissiadis YE; Hollywood Radiation Oncology, GenesisCare, WA, Australia. Electronic address: Yvonne.Zissiadis@genesiscare.com., Poortmans P; Iridium Netwerk and University of Antwerp, Wilrijk Antwerp, Belgium. Electronic address: Philip.poortmans@telenet.be., Kaidar-Person O; Sheba Medical Center, Ramat Gan, Israel GROW-School for Oncology and Developmental Biology or GROW (Maastro), Maastricht University, Maastricht, the Netherlands; Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel. Electronic address: Orit.KaidarPerson@Sheba.health.gov.il.
Jazyk: angličtina
Zdroj: Critical reviews in oncology/hematology [Crit Rev Oncol Hematol] 2021 Jul; Vol. 163, pp. 103391. Date of Electronic Publication: 2021 Jun 05.
DOI: 10.1016/j.critrevonc.2021.103391
Abstrakt: Purpose: Post mastectomy radiation therapy (PMRT) reduces locoregional recurrence (LRR) and breast cancer mortality for selected patients. Bolus overcomes the skin-sparing effect of external-beam radiotherapy, ensuring adequate dose to superficial regions at risk of local recurrence (LR). This systematic review summarizes the current evidence regarding the impact of bolus on LR and acute toxicity in the setting of PMRT.
Results: 27 studies were included. The use of bolus led to higher rates of acute grade 3 radiation dermatitis (pooled rates of 9.6% with bolus vs. 1.2% without). Pooled crude LR rates from thirteen studies (n = 3756) were similar with (3.5%) and without (3.6%) bolus.
Conclusions: Bolus may be indicated in cases with a high risk of LR in the skin, but seems not to be necessary for all patients. Further work is needed to define the role of bolus in PMRT.
(Copyright © 2021 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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