Mantle cell lymphoma, malt lymphoma, small lymphocytic lymphoma, and follicular lymphoma of the oral cavity: An update.

Autor: Wagner VP; Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas, Piracicaba, Brazil.; Academic Unit of Oral and Maxillofacial Medicine and Pathology, Department of Clinical Dentistry, University of Sheffield, Sheffield, UK., Rodrigues-Fernandes CI; Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas, Piracicaba, Brazil., Carvalho MVR; Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas, Piracicaba, Brazil., Dos Santos JN; Department of Oral Pathology, School of Dentistry, Federal University of Bahia, Salvador, Brazil., Barra MB; Pathology Service, Moinhos de Vento Hospital, Porto Alegre, Brazil., Hunter KD; Academic Unit of Oral and Maxillofacial Medicine and Pathology, Department of Clinical Dentistry, University of Sheffield, Sheffield, UK.; Department of Oral Biology and Pathology, School of Dentistry, University of Pretoria, Pretoria, South Africa., Aguirre-Urizar JM; Unit of Oral Pathology and Medicine, Department of Stomatology II, University of the Basque Country/EHU, Leioa, Spain., van Heerden WFP; Department of Oral Biology and Pathology, School of Dentistry, University of Pretoria, Pretoria, South Africa., Vargas PA; Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas, Piracicaba, Brazil.; Department of Oral Biology and Pathology, School of Dentistry, University of Pretoria, Pretoria, South Africa., Fonseca FP; Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas, Piracicaba, Brazil.; Department of Oral Biology and Pathology, School of Dentistry, University of Pretoria, Pretoria, South Africa.; Department of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil., Martins MD; Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas, Piracicaba, Brazil.; Department of Pathology, School of Dentistry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
Jazyk: angličtina
Zdroj: Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology [J Oral Pathol Med] 2021 Jul; Vol. 50 (6), pp. 622-630. Date of Electronic Publication: 2021 Jul 01.
DOI: 10.1111/jop.13214
Abstrakt: Background: Although uncommon, mature small B-cell lymphomas may arise in the oral/maxillofacial area and oral pathologists must be aware of the key characteristics of these neoplasms to perform an accurate diagnosis. In this manuscript, we attempted to integrate the currently available data on the clinicopathological features of follicular lymphoma (FL), mantle cell lymphoma (MCL), extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT-L), and chronic lymphocytic leukemia/ small lymphocytic lymphoma (CLL/SLL) affecting these anatomical regions.
Methods: An updated descriptive literature review was carried out and a detailed electronic search was done in multiple databases to gather all cases affecting the oral/maxillofacial region and palatine tonsils.
Results: We observed that MALT-L was the most frequently reported subtype, followed by FL, MCL, and CLL/SLL. The palate was affected in a high proportion of cases and the most usual clinical presentation was an asymptomatic swelling. MALT-L and CLL/SLL neoplastic cells were strongly associated with small salivary glands. FL showed no gender preference, while MCL and CLL/SLL were more prevalent in males and MALT-L in females. Overall, cases were more common in elderly individuals. Patients' treatment and outcome varied, with MCL being the most aggressive neoplasm with a dismal prognosis in comparison to FL and MALT-L.
Conclusion: Despite the poor documentation in many of the cases available, especially regarding the microscopic and molecular features of tumors, this review demonstrated that the oral mature small B-cell lymphomas investigated share similar clinical presentation, but carry different prognostic significance, demanding an accurate diagnosis.
(© 2021 The Authors. Journal of Oral Pathology & Medicine published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
Externí odkaz: