| Autor: |
Ben Izhak M; The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel., Eshel A; Azrieli Faculty of Medicine, Bar Ilan University, Safed, Israel., Cohen R; HY-Laboratories Ltd., Rehovot, Israel., Madar-Shapiro L; HY-Laboratories Ltd., Rehovot, Israel., Meiri H; HY-Laboratories Ltd., Rehovot, Israel., Wachtel C; HY-Laboratories Ltd., Rehovot, Israel., Leung C; GENEWIZ, South Plainfield, New Jersey, USA., Messick E; GENEWIZ, South Plainfield, New Jersey, USA., Jongkam N; GENEWIZ, South Plainfield, New Jersey, USA., Mavor E; Bariatric Surgery Unit, Surgery Division, Kaplan Medical Center, Rehovot, Israel., Sapozhnikov S; Bariatric Surgery Unit, Surgery Division, Kaplan Medical Center, Rehovot, Israel., Maharshak N; IBD Unit and Bacteriotherapy Clinic, Department of Gastroenterology and Liver Diseases, Tel Aviv Medical Center and Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel., Abu-Abeid S; Bariatric Surgery Unit, General Surgery Department, Tel-Aviv Medical Center and Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel., Alis A; Department of Internal Medicine C, Beilinson Hospital, Rabin Medical Center, Petach Tikva, Israel., Mahler I; Department of Internal Medicine C, Beilinson Hospital, Rabin Medical Center, Petach Tikva, Israel.; Bariatric Surgery, Asuta Medical Center, Ramat Ha'Chayal, Tel Aviv, Israel., Meoded A; Bariatric Surgery Unit, The Baruch Padeh Medical Center, Poria, Israel., Meron Eldar S; IBD Unit and Bacteriotherapy Clinic, Department of Gastroenterology and Liver Diseases, Tel Aviv Medical Center and Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel., Koren O; Azrieli Faculty of Medicine, Bar Ilan University, Safed, Israel., Louzoun Y; Department of Mathematics, Bar-Ilan University, Ramat Gan, Israel. |
| Abstrakt: |
Bariatric surgery is often the preferred method to resolve obesity and diabetes, with ∼800,000 cases worldwide yearly and high outcome variability. The ability to predict the long-term body mass index (BMI) change following surgery has important implications for individuals and the health care system in general. Given the tight connection between eating habits, sugar consumption, BMI, and the gut microbiome, we tested whether the microbiome before any treatment is associated with different treatment outcomes, as well as other intakes (high-density lipoproteins [HDL], triglycerides, etc.). A projection of the gut microbiome composition of obese (sampled before and after bariatric surgery) and lean patients into principal components was performed, and the relation between this projection and surgery outcome was studied. The projection revealed three different microbiome profiles belonging to lean, obese, and obese individuals who underwent bariatric surgery, with the postsurgery microbiome more different from the lean microbiome than the obese microbiome. The same projection allowed for a prediction of BMI loss following bariatric surgery, using only the presurgery microbiome. The microbial changes following surgery were an increase in the relative abundance of Proteobacteria and Fusobacteria and a decrease in Firmicutes . The gut microbiome can be decomposed into main components depicting the patient's development and predicting in advance the outcome. Those may be translated into the better clinical management of obese individuals planning to undergo metabolic surgery. IMPORTANCE BMI and diabetes can affect the gut microbiome composition. Bariatric surgery has large variabilities in the outcome. The microbiome was previously shown to be a good predictor for multiple diseases. We analyzed here the gut microbiome before and after bariatric surgery and showed the following. (i) The microbiome before surgery can be used to predict surgery outcomes. (ii) The postsurgery microbiome drifts further away from the lean microbiome than the microbiome of the presurgery obese patients. These results can lead to a microbiome-based presurgery decision whether to perform surgery. |
