History of heart failure in patients with coronavirus disease 2019: Insights from a French registry.

Autor: Panagides V; Aix-Marseille Université, Intensive Care Unit, Hôpital Nord, AP-HM, 13015 Marseille, France., Vincent F; Centre Hospitalier Universitaire de Lille, Institut Cœur Poumon, Cardiology, Department of Interventional Cardiology for Coronary, Valves and Structural Heart Diseases, INSERM U1011, Institut Pasteur de Lille, EGID, Université de Lille, 59800 Lille, France., Weizman O; Institut Lorrain du Cœur et des Vaisseaux, CHU de Nancy, 54500 Vandœuvre-les-Nancy, France; Université de Paris, Paris Cardiovascular Research Centre (PARCC), INSERM, UMR-S970, 75015 Paris, France., Jonveaux M; Département de Cardiologie, Expert Valve Center, Assistance Publique-Hôpitaux de Paris, Hôpital Henri Mondor, 94010 Créteil, France., Trimaille A; Nouvel Hôpital Civil, Centre Hospitalier Régional Universitaire de Strasbourg, 67000 Strasbourg, France., Pommier T; Centre Hospitalier Universitaire de Dijon, 21000 Dijon, France., Cellier J; Hôpital Européen Georges-Pompidou, Université de Paris, 75015 Paris, France., Geneste L; Centre Hospitalier Universitaire d'Amiens-Picardie, 80000 Amiens, France., Marsou W; GCS-Groupement des Hôpitaux de l'Institut Catholique de Lille, Faculté de Médecine et de Maïeutique, Université Catholique de Lille, 59800 Lille, France., Deney A; Centre Hospitalier Universitaire de Toulouse, 31400 Toulouse, France., Attou S; Centre Hospitalier Universitaire de Caen-Normandie, 14000 Caen, France., Delmotte T; Centre Hospitalier Universitaire de Reims, 51100 Reims, France., Fauvel C; Rouen University Hospital, FHU REMOD-VHF, 76000 Rouen, France., Ezzouhairi N; University of Bordeaux, Hôpital Cardiologique Haut-Lévêque, Centre Hospitalier Universitaire de Bordeaux, Pessac, France., Perin B; Institut Lorrain du Cœur et des Vaisseaux, CHU de Nancy, 54500 Vandœuvre-les-Nancy, France., Zakine C; Clinique Saint-Gatien, 37540 Saint-Cyr-sur-Loire, France., Levasseur T; Centre Hospitalier Intercommunal Fréjus-Saint-Raphaël, 83600 Fréjus, France., Ma I; Hôpital Européen Georges-Pompidou, Université de Paris, 75015 Paris, France., Chavignier D; Centre Hospitalier Régional d'Orléans, 45100 Orléans, France., Noirclerc N; Centre Hospitalier Annecy Genevois, 74370 Épagny-Metz-Tessy, France., Darmon A; Hôpital Bichat-Claude-Bernard, AP-HP, Université de Paris, 75018 Paris, France., Mevelec M; Centre Hospitalier Annecy Genevois, 74370 Épagny-Metz-Tessy, France., Karsenty C; Centre Hospitalier Universitaire de Toulouse, 31400 Toulouse, France., Duceau B; Département de Cardiologie, Expert Valve Center, Assistance Publique-Hôpitaux de Paris, Hôpital Henri Mondor, 94010 Créteil, France., Sutter W; Département de Cardiologie, Expert Valve Center, Assistance Publique-Hôpitaux de Paris, Hôpital Henri Mondor, 94010 Créteil, France., Mika D; Université Paris-Saclay, INSERM, UMR-S 1180, 92296 Châtenay-Malabry, France., Pezel T; Hôpital Lariboisière, AP-HP, University of Paris, 75010 Paris, France., Waldmann V; Département de Cardiologie, Expert Valve Center, Assistance Publique-Hôpitaux de Paris, Hôpital Henri Mondor, 94010 Créteil, France., Ternacle J; University of Bordeaux, Hôpital Cardiologique Haut-Lévêque, Centre Hospitalier Universitaire de Bordeaux, Pessac, France; Institut Universitaire de Cardiologie et de Pneumologie de Québec, Université Laval/Québec Heart and Lung Institute, Laval University, Québec G1V 4G5, Canada., Cohen A; Hôpital Saint-Antoine, 75012 Paris, France. Electronic address: ariel.cohen@aphp.fr., Bonnet G; Université de Paris, Paris Cardiovascular Research Centre (PARCC), INSERM, UMR-S970, 75015 Paris, France; University of Bordeaux, Hôpital Cardiologique Haut-Lévêque, Centre Hospitalier Universitaire de Bordeaux, Pessac, France.
Jazyk: angličtina
Zdroj: Archives of cardiovascular diseases [Arch Cardiovasc Dis] 2021 May; Vol. 114 (5), pp. 415-425. Date of Electronic Publication: 2021 May 24.
DOI: 10.1016/j.acvd.2021.04.003
Abstrakt: Background: Although cardiovascular comorbidities seem to be strongly associated with worse outcomes in patients with coronavirus disease 2019 (COVID-19), data regarding patients with preexisting heart failure are limited.
Aims: To investigate the incidence, characteristics and clinical outcomes of patients with COVID-19 with a history of heart failure with preserved or reduced ejection fraction.
Methods: We performed an observational multicentre study including all patients hospitalized for COVID-19 across 24 centres in France from 26 February to 20 April 2020. The primary endpoint was a composite of in-hospital death or need for orotracheal intubation.
Results: Overall, 2809 patients (mean age 66.4±16.9years) were included. Three hundred and seventeen patients (11.2%) had a history of heart failure; among them, 49.2% had heart failure with reduced ejection fraction and 50.8% had heart failure with preserved ejection fraction. COVID-19 severity at admission, defined by a quick sequential organ failure assessment score>1, was similar in patients with versus without a history of heart failure. Before and after adjustment for age, male sex, cardiovascular comorbidities and quick sequential organ failure assessment score, history of heart failure was associated with the primary endpoint (hazard ratio [HR]: 1.41, 95% confidence interval [CI]: 1.06-1.90; P=0.02). This result seemed to be mainly driven by a history of heart failure with preserved ejection fraction (HR: 1.61, 95% CI: 1.13-2.27; P=0.01) rather than heart failure with reduced ejection fraction (HR: 1.19, 95% CI: 0.79-1.81; P=0.41).
Conclusions: History of heart failure in patients with COVID-19 was associated with a higher risk of in-hospital death or orotracheal intubation. These findings suggest that patients with a history of heart failure, particularly heart failure with preserved ejection fraction, should be considered at high risk of clinical deterioration.
(Copyright © 2021. Published by Elsevier Masson SAS.)
Databáze: MEDLINE
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