The role of Nrf2 in autoimmunity and infectious disease: Therapeutic possibilities.

Autor:	Freeborn RA; Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI, United States; Institute for Integrative Toxicology, Michigan State University, East Lansing, MI, United States., Rockwell CE; Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI, United States; Institute for Integrative Toxicology, Michigan State University, East Lansing, MI, United States; Cell and Molecular Biology Program, Michigan State University, East Lansing, MI, United States. Electronic address: rockwelc@msu.edu.
Jazyk:	angličtina
Zdroj:	Advances in pharmacology (San Diego, Calif.) [Adv Pharmacol] 2021; Vol. 91, pp. 61-110. Date of Electronic Publication: 2021 Apr 08.
DOI:	10.1016/bs.apha.2020.10.003
Abstrakt:	Nrf2 is a cytoprotective transcription factor which is involved in ameliorating oxidative stress and toxic insults. Recently, an immunomodulatory role for Nrf2 has gained appreciation as it has been shown to protect cells and hosts alike in a variety of immune and inflammatory disorders. However, Nrf2 utilizes numerous distinct pathways to elicit its immunomodulatory effects. In this review, we summarize the literature discussing the roles of Nrf2 in autoimmunity and infectious diseases with a goal of understanding the potential to therapeutically target Nrf2. Competing Interests: Conflict of interest statement The authors declare that they have no conflicts of interest. (Copyright © 2021 Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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