Dental tissue-derived stem cell sheet biotechnology for periodontal tissue regeneration: A systematic review.

Autor: Magalhães FD; Graduation Dentistry Program, Ibirapuera University, Av. Interlagos 1329 - 4º, Chácara Flora, São Paulo, SP, ZIP code: 04661-100, Brazil., Sarra G; Department of Restorative Dentistry, School of Dentistry, Universidade de São Paulo, Av. Prof. Lineu Prestes 2227, São Paulo, SP, ZIP code: 05508-000, Brazil., Carvalho GL; A.C. Camargo Cancer Center, Stomatology Department, Rua Tamandaré 753, Liberdade, São Paulo, SP, Zip code: 01525-001, Brazil., Pedroni ACF; Graduation Dentistry Program, Ibirapuera University, Av. Interlagos 1329 - 4º, Chácara Flora, São Paulo, SP, ZIP code: 04661-100, Brazil., Marques MM; Graduation Dentistry Program, Ibirapuera University, Av. Interlagos 1329 - 4º, Chácara Flora, São Paulo, SP, ZIP code: 04661-100, Brazil., Chambrone L; Graduation Dentistry Program, Ibirapuera University, Av. Interlagos 1329 - 4º, Chácara Flora, São Paulo, SP, ZIP code: 04661-100, Brazil., Gimenez T; Graduation Dentistry Program, Ibirapuera University, Av. Interlagos 1329 - 4º, Chácara Flora, São Paulo, SP, ZIP code: 04661-100, Brazil., Moreira MS; Graduation Dentistry Program, Ibirapuera University, Av. Interlagos 1329 - 4º, Chácara Flora, São Paulo, SP, ZIP code: 04661-100, Brazil; A.C. Camargo Cancer Center, Stomatology Department, Rua Tamandaré 753, Liberdade, São Paulo, SP, Zip code: 01525-001, Brazil. Electronic address: stellam@usp.br.
Jazyk: angličtina
Zdroj: Archives of oral biology [Arch Oral Biol] 2021 Sep; Vol. 129, pp. 105182. Date of Electronic Publication: 2021 Jun 01.
DOI: 10.1016/j.archoralbio.2021.105182
Abstrakt: Objective: This study aimed to conduct a systematic review of the use of a cell sheet formed by mesenchymal stem cells derived from dental tissues (ddMSCs) for periodontal tissue regeneration in animal models in comparison with any other type of regenerative treatment.
Design: PubMed and Scopus databases were searched for relevant studies up to December 2020. The review was conducted based on the Preferred Reporting Items for Systematic Reviews and Meta-analysis guidelines.
Results: Of the 1542 potentially relevant articles initially identified, 33 fulfilled the eligibility criteria and were considered for this review. Even with a wide variety of selected study methods, the periodontal tissue was always regenerated; this indicates the potential for the use of these cell sheets in the future of periodontics. However, this regeneration process is not always complete.
Conclusion: Despite the implantation, ddMSCs sheets have a great potential to be used in the regeneration of periodontal tissue. More in vivo studies should be conducted using standardized techniques for cell sheet implantation to obtain more robust evidence of the relevance of using this modality of cell therapy for periodontal tissue regeneration.
(Copyright © 2021 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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