| Autor: |
Kavanaugh LG; Biochemistry Department, Emory University, Atlanta, Georgia, USA.; Biological Sciences Department, University of North Carolina at Charlotte, Charlotte, North Carolina, USA., Harrison SK; Biological Sciences Department, University of North Carolina at Charlotte, Charlotte, North Carolina, USA., Flanagan JN; Biological Sciences Department, University of North Carolina at Charlotte, Charlotte, North Carolina, USA., Steck TR; Biological Sciences Department, University of North Carolina at Charlotte, Charlotte, North Carolina, USA. |
| Abstrakt: |
Antibiotic collateral sensitivity, in which acquired resistance to one drug leads to decreased resistance to a different drug, occurs in Burkholderia multivorans. Here, we observed that treatment of extensively drug-resistant variants evolved from a cystic fibrosis (CF) sputum sample isolate with either meropenem or sulfamethoxazole-trimethoprim, depending on past resistance phenotypes, resulted in increased sensitivity to five different classes of antibiotics. We further identified mutations, including putative resistance-nodulation-division efflux pump regulators and uncharacterized pumps, that may be involved in this phenotype in B. multivorans. |
