| Autor: |
Shamaei M; Chronic Respiratory Disease Research Center, NRITLD, Masih Daneshvari Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.; Darabad, NRITLD, Masih Daneshvari Hospital, Tehran, Iran., Mirsaeidi M; University of Miami, Division of Pulmonary and Critical Care, Miami, Florida, USA. |
| Jazyk: |
angličtina |
| Zdroj: |
Infection and immunity [Infect Immun] 2021 Jul 15; Vol. 89 (8), pp. e0081220. Date of Electronic Publication: 2021 Jul 15. |
| DOI: |
10.1128/IAI.00812-20 |
| Abstrakt: |
Although nontuberculous mycobacteria (NTM) are considered opportunistic infections, incidence and prevalence of NTM infection are increasing worldwide becoming a major public health threat. Innate immunity plays an essential role in mediating the initial host response against these intracellular bacteria. Specifically, macrophages phagocytose and eliminate NTM and act as antigen-presenting cells, which trigger downstream activation of cellular and humoral adaptive immune responses. Identification of macrophage receptors, mycobacterial ligands, phagosome maturation, autophagy/necrosis, and escape mechanisms are important components of this immunity network. The role of the macrophage in mycobacterial disease has mainly been studied in tuberculosis (TB), but limited information exists on its role in NTM. In this review, we focus on NTM immunity, the role of macrophages, and host interaction in NTM infection. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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