An approach to fast 2D nuclear magnetic resonance at low concentration based on p-H 2 -induced polarization and nonuniform sampling.

Autor: Aspers RLEG; Institute for Molecules and Materials, Radboud University, Nijmegen, The Netherlands., Tessari M; Institute for Molecules and Materials, Radboud University, Nijmegen, The Netherlands.
Jazyk: angličtina
Zdroj: Magnetic resonance in chemistry : MRC [Magn Reson Chem] 2021 Dec; Vol. 59 (12), pp. 1236-1243. Date of Electronic Publication: 2021 Jun 06.
DOI: 10.1002/mrc.5182
Abstrakt: Recent developments in para-hydrogen-induced polarization (PHIP) methods allow the nuclear magnetic resonance (NMR) detection of specific classes of compounds, down to sub-micromolar concentration in solution. However, when dealing with complex mixtures, signal resolution requires the acquisition of 2D PHIP-NMR spectra, which often results in long experimental times. This strongly limits the applicability of these 2D PHIP-NMR techniques in areas in which high-throughput analysis is required. Here, we present a combination of fast acquisition and nonuniform sampling that can afford a 10-fold reduction in measuring time without compromising the spectral quality. This approach was tested on a mixture of substrates at micromolar concentration, for which a resolved 2D PHIP spectrum was acquired in less than 3 min.
(© 2021 The Authors. Magnetic Resonance in Chemistry published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje