Associations between subregional thalamic volume and brain pathology in autosomal dominant Alzheimer's disease.

Autor:	Pardilla-Delgado E; Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA., Torrico-Teave H; Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA., Sanchez JS; Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA., Ramirez-Gomez LA; Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA., Baena A; Grupo de Neurociencias de Antioquia, Universidad de Antioquia, Medellin 050010, Colombia., Bocanegra Y; Grupo de Neurociencias de Antioquia, Universidad de Antioquia, Medellin 050010, Colombia., Vila-Castelar C; Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA., Fox-Fuller JT; Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.; Boston University, Boston, MA 02215, USA., Guzmán-Vélez E; Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA., Martínez J; Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA., Alvarez S; Hospital Pablo Tobon Uribe, Medellin 050034, Colombia., Ochoa-Escudero M; Hospital Pablo Tobon Uribe, Medellin 050034, Colombia., Lopera F; Grupo de Neurociencias de Antioquia, Universidad de Antioquia, Medellin 050010, Colombia., Quiroz YT; Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.; Grupo de Neurociencias de Antioquia, Universidad de Antioquia, Medellin 050010, Colombia.
Jazyk:	angličtina
Zdroj:	Brain communications [Brain Commun] 2021 May 10; Vol. 3 (2), pp. fcab101. Date of Electronic Publication: 2021 May 10 (Print Publication: 2021).
DOI:	10.1093/braincomms/fcab101
Abstrakt:	Histopathological reports suggest that subregions of the thalamus, which regulates multiple physiological and cognitive processes, are not uniformly affected by Alzheimer's disease. Despite this, structural neuroimaging studies often consider the thalamus as a single region. Identification of in vivo Alzheimer's-dependent volumetric changes in thalamic subregions may aid the characterization of early nuclei-specific neurodegeneration in Alzheimer's disease. Here, we leveraged access to the largest single-mutation cohort of autosomal-dominant Alzheimer's disease to test whether cross-sectional abnormalities in subregional thalamic volumes are evident in non-demented mutation carriers ( n  = 31), compared to non-carriers ( n  = 36), and whether subregional thalamic volume is associated with age, markers of brain pathology and cognitive performance. Using automatic parcellation we examined the thalamus in six subregions (anterior, lateral, ventral, intralaminar, medial, and posterior) and their relation to age and brain pathology (amyloid and tau), as measured by PET imaging. No between-group differences were observed in the volume of the thalamic subregions. In carriers, lower volume in the medial subregion was related to increased cortical amyloid and entorhinal tau burden. These findings suggest that thalamic Alzheimer's-related volumetric reductions are not uniform even in preclinical and prodromal stages of autosomal-dominant Alzheimer's disease and therefore, this structure should not be considered as a single, unitary structure in Alzheimer's disease research. (© The Author(s) (2021). Published by Oxford University Press on behalf of the Guarantors of Brain.)
Databáze:	MEDLINE
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